OBJECTIVE: To identify determinants of medication compliance and low-density lipoprotein cholesterol goal attainment. STUDY DESIGN: This retrospective analysis used claims data from a large, national, employment-based independent practice association database. Subjects were identified based on the existence of a filled prescription for statin therapy between April 1, 1999, and June 30, 2001. Subjects had to be 18 years or older, continuously enrolled in the health plan for 2 years, and new users of statin therapy. METHODS: Multivariate logistic regression models were used to identify predictors of compliance and goal attainment in high-risk subjects. RESULTS: As the mean copayment for statins increased, there was a decrease in the likelihood of compliance. Of the subjects with laboratory results, 50.7% attained their low-density lipoprotein cholesterol goal level established by National Cholesterol Education Program Adult Treatment Panel III guidelines. Older individuals and men were more likely to reach their low-density lipoprotein cholesterol target goal, as were individuals who were compliant with their statin therapy. CONCLUSIONS: Compliance with statin therapy in the managed care setting remains poor. Of particular concern is the lower level of compliance among women and younger high-risk patients, along with patients who have fewer outpatient visits associated with hyperlipidemia and lower incidences of cholesterol testing.
OBJECTIVE: To identify determinants of medication compliance and low-density lipoprotein cholesterol goal attainment. STUDY DESIGN: This retrospective analysis used claims data from a large, national, employment-based independent practice association database. Subjects were identified based on the existence of a filled prescription for statin therapy between April 1, 1999, and June 30, 2001. Subjects had to be 18 years or older, continuously enrolled in the health plan for 2 years, and new users of statin therapy. METHODS: Multivariate logistic regression models were used to identify predictors of compliance and goal attainment in high-risk subjects. RESULTS: As the mean copayment for statins increased, there was a decrease in the likelihood of compliance. Of the subjects with laboratory results, 50.7% attained their low-density lipoprotein cholesterol goal level established by National Cholesterol Education Program Adult Treatment Panel III guidelines. Older individuals and men were more likely to reach their low-density lipoprotein cholesterol target goal, as were individuals who were compliant with their statin therapy. CONCLUSIONS: Compliance with statin therapy in the managed care setting remains poor. Of particular concern is the lower level of compliance among women and younger high-risk patients, along with patients who have fewer outpatient visits associated with hyperlipidemia and lower incidences of cholesterol testing.
Authors: Virginia Wang; Chuan-Fen Liu; Christopher L Bryson; Nancy D Sharp; Matthew L Maciejewski Journal: Health Serv Res Date: 2011-06-20 Impact factor: 3.402
Authors: Niek C A van de Pas; Johan A C Rullmann; Ruud A Woutersen; Ben van Ommen; Ivonne M C M Rietjens; Albert A de Graaf Journal: J Pharmacokinet Pharmacodyn Date: 2014-08-09 Impact factor: 2.745
Authors: Carlo M Rotella; Augusto Zaninelli; Cristina Le Grazie; Mary E Hanson; Gian Franco Gensini Journal: Lipids Health Dis Date: 2010-07-27 Impact factor: 3.876