M W Pound1, D B May. 1. Department of Pharmacy Practice, Campbell University School of Pharmacy, Buies Creek, NC 27506, USA. mpound@capefearvalley.com
Abstract
OBJECTIVE: To review the aetiologies and preventative methods associated with Jarisch-Herxheimer reactions (JHR). DATA SOURCES: Ovid Medline (1966-June Week 1 2004) was utilized to assess biomedical literature; a review of the bibliographies of articles was also performed. DATA SYNTHESIS: JHR often occurs with the treatment of spirochete infections. However, the mechanism by which the reaction takes place is not clearly defined. CONCLUSION: Studies suggest with conflicting evidence that the JHR is caused by release of endotoxin-like material from the spirochete as well as cytokine elevation in the body. It appears the type of drug and the rate of spirochete clearance from the body have little effect on the incidence of the reaction. Many pretreatment options have been explored with limited efficacy with the exception of anti-tumour necrosis factor antibodies.
OBJECTIVE: To review the aetiologies and preventative methods associated with Jarisch-Herxheimer reactions (JHR). DATA SOURCES: Ovid Medline (1966-June Week 1 2004) was utilized to assess biomedical literature; a review of the bibliographies of articles was also performed. DATA SYNTHESIS: JHR often occurs with the treatment of spirochete infections. However, the mechanism by which the reaction takes place is not clearly defined. CONCLUSION: Studies suggest with conflicting evidence that the JHR is caused by release of endotoxin-like material from the spirochete as well as cytokine elevation in the body. It appears the type of drug and the rate of spirochete clearance from the body have little effect on the incidence of the reaction. Many pretreatment options have been explored with limited efficacy with the exception of anti-tumour necrosis factor antibodies.
Authors: Tais F Galvao; Marcus T Silva; Suzanne J Serruya; Lori M Newman; Jeffrey D Klausner; Mauricio G Pereira; Ricardo Fescina Journal: PLoS One Date: 2013-02-21 Impact factor: 3.240
Authors: Stephan Spiller; Greg Elson; Ruth Ferstl; Stefan Dreher; Thomas Mueller; Marina Freudenberg; Bruno Daubeuf; Hermann Wagner; Carsten J Kirschning Journal: J Exp Med Date: 2008-07-21 Impact factor: 14.307