| Literature DB >> 15895597 |
Regine Choe1, Alper Corlu, Kijoon Lee, Turgut Durduran, Soren D Konecky, Monika Grosicka-Koptyra, Simon R Arridge, Brian J Czerniecki, Douglas L Fraker, Angela DeMichele, Britton Chance, Mark A Rosen, Arjun G Yodh.
Abstract
We employ diffuse optical tomography (DOT) to track treatment progress in a female subject presenting with locally advanced invasive carcinoma of the breast during neoadjuvant chemotherapy. Three-dimensional images of total hemoglobin concentration and scattering identified the tumor. Our measurements reveal tumor shrinkage during the course of chemotherapy, in reasonable agreement with magnetic resonance images of the same subject. A decrease in total hemoglobin concentration contrast between tumor and normal tissue was also observed over time. The results demonstrate the potential of DOT for measuring physiological parameters of breast lesions during chemotherapy.Entities:
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Year: 2005 PMID: 15895597 DOI: 10.1118/1.1869612
Source DB: PubMed Journal: Med Phys ISSN: 0094-2405 Impact factor: 4.071