Literature DB >> 15895248

Subcellular localization and trafficking of polycystins.

Michael Köttgen1, Gerd Walz.   

Abstract

Polycystin-2 is a member of the transient receptor potential (TRP) family of ion channels that is mutated in autosomal dominant polycystic kidney disease. Although its function as a non-selective cation channel has been demonstrated in several model systems, the precise subcellular localization of polycystin-2 (TRPP2) in tubular epithelial cells has remained controversial. Recent evidence suggests that the subcellular localization of TRPP2 is regulated by multiple protein interactions. This review will summarize our current knowledge about polycystin trafficking and highlight the experimental data that supports a compartment-specific function of 'cystogenic' proteins.

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Year:  2005        PMID： 15895248     DOI： 10.1007/s00424-005-1417-3

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  85 in total

1.  Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene.

Authors:  Lukas Foggensteiner; A Paul Bevan; Ruth Thomas; Nicholas Coleman; Catherine Boulter; John Bradley; Oxana Ibraghimov-Beskrovnaya; Katherine Klinger; Richard Sandford
Journal:  J Am Soc Nephrol       Date:  2000-05       Impact factor: 10.121

2.  Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease.

Authors:  P M Vassilev; L Guo; X Z Chen; Y Segal; J B Peng; N Basora; H Babakhanlou; G Cruger; M Kanazirska; E M Brown; M A Hediger; J Zhou
Journal:  Biochem Biophys Res Commun       Date:  2001-03-23       Impact factor: 3.575

3.  Polycystin-2 expression is developmentally regulated.

Authors:  G S Markowitz; Y Cai; L Li; G Wu; L C Ward; S Somlo; V D D'Agati
Journal:  Am J Physiol       Date:  1999-07

4.  Polarized dendritic transport and the AP-1 mu1 clathrin adaptor UNC-101 localize odorant receptors to olfactory cilia.

Authors:  N D Dwyer; C E Adler; J G Crump; N D L'Etoile; C I Bargmann
Journal:  Neuron       Date:  2001-08-02       Impact factor: 17.173

5.  Peptides from the PKD repeats of polycystin, the PKD1 gene product, modulate pattern formation in the developing kidney.

Authors:  J van Adelsberg
Journal:  Dev Genet       Date:  1999

6.  Characterization and cell distribution of polycystin, the product of autosomal dominant polycystic kidney disease gene 1.

Authors:  R Palsson; C P Sharma; K Kim; M McLaughlin; D Brown; M A Arnaout
Journal:  Mol Med       Date:  1996-11       Impact factor: 6.354

7.  Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1.

Authors:  O Ibraghimov-Beskrovnaya; N O Bukanov; L C Donohue; W R Dackowski; K W Klinger; G M Landes
Journal:  Hum Mol Genet       Date:  2000-07-01       Impact factor: 6.150

Review 8.  Caenorhabditis elegans as a model to study renal development and disease: sexy cilia.

Authors:  Maureen M Barr
Journal:  J Am Soc Nephrol       Date:  2005-01-12       Impact factor: 10.121

9.  The KLP-6 kinesin is required for male mating behaviors and polycystin localization in Caenorhabditis elegans.

Authors:  Erik M Peden; Maureen M Barr
Journal:  Curr Biol       Date:  2005-03-08       Impact factor: 10.834

Review 10.  Regulation of calcium signaling by polycystin-2.

Authors:  Horacio F Cantiello
Journal:  Am J Physiol Renal Physiol       Date:  2004-06
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  34 in total

Review 1.  Intermediate filaments: a role in epithelial polarity.

Authors:  Andrea S Oriolo; Flavia A Wald; Victoria P Ramsauer; Pedro J I Salas
Journal:  Exp Cell Res       Date:  2007-03-12       Impact factor: 3.905

Review 2.  Function and regulation of TRPP2 at the plasma membrane.

Authors:  Leonidas Tsiokas
Journal:  Am J Physiol Renal Physiol       Date:  2009-02-25

3.  Activation of TRPP2 through mDia1-dependent voltage gating.

Authors:  Chang-Xi Bai; Sehyun Kim; Wei-Ping Li; Andrew J Streets; Albert C M Ong; Leonidas Tsiokas
Journal:  EMBO J       Date:  2008-04-03       Impact factor: 11.598

Review 4.  Transient receptor potential channelopathies.

Authors:  Bernd Nilius; Grzegorz Owsianik
Journal:  Pflugers Arch       Date:  2010-02-04       Impact factor: 3.657

Review 5.  The role of transient receptor potential polycystin channels in bone diseases.

Authors:  Maria A Katsianou; Foteini G Skondra; Antonios N Gargalionis; Christina Piperi; Efthimia K Basdra
Journal:  Ann Transl Med       Date:  2018-06

Review 6.  TRP channels: a TR(I)P through a world of multifunctional cation channels.

Authors:  Bernd Nilius; Thomas Voets
Journal:  Pflugers Arch       Date:  2005-07-13       Impact factor: 3.657

Review 7.  The versatile nature of the calcium-permeable cation channel TRPP2.

Authors:  Aurélie Giamarchi; Françoise Padilla; Bertrand Coste; Matthieu Raoux; Marcel Crest; Eric Honoré; Patrick Delmas
Journal:  EMBO Rep       Date:  2006-08       Impact factor: 8.807

Review 8.  Decoding calcium signaling across the nucleus.

Authors:  André G Oliveira; Erika S Guimarães; Lídia M Andrade; Gustavo B Menezes; M Fatima Leite
Journal:  Physiology (Bethesda)       Date:  2014-09

Review 9.  Primary cilia and dendritic spines: different but similar signaling compartments.

Authors:  Inna V Nechipurenko; David B Doroquez; Piali Sengupta
Journal:  Mol Cells       Date:  2013-09-16       Impact factor: 5.034

10.  A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes.

Authors:  Aurélie Giamarchi; Shuang Feng; Lise Rodat-Despoix; Yaoxian Xu; Ekaterina Bubenshchikova; Linda J Newby; Jizhe Hao; Christelle Gaudioso; Marcel Crest; Andrei N Lupas; Eric Honoré; Michael P Williamson; Tomoko Obara; Albert C M Ong; Patrick Delmas
Journal:  EMBO J       Date:  2010-02-18       Impact factor: 11.598
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