Literature DB >> 15647338

Caenorhabditis elegans as a model to study renal development and disease: sexy cilia.

Maureen M Barr1.   

Abstract

The nematode Caenorhabditis elegans has no kidney per se, yet "the worm" has proved to be an excellent model to study renal-related issues, including tubulogenesis of the excretory canal, membrane transport and ion channel function, and human genetic diseases including autosomal dominant polycystic kidney disease (ADPKD). The goal of this review is to explain how C. elegans has provided insight into cilia development, cilia function, and human cystic kidney diseases.

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Year:  2005        PMID： 15647338     DOI： 10.1681/ASN.2004080645

Source DB:  PubMed          Journal:  J Am Soc Nephrol        ISSN： 1046-6673            Impact factor:   10.121


  20 in total

1.  Translational Geroscience: From invertebrate models to companion animal and human interventions.

Authors:  Mitchell B Lee; Matt Kaeberlein
Journal:  Transl Med Aging       Date:  2018-08-17

Review 2.  Small GTPases and cilia.

Authors:  Yujie Li; Jinghua Hu
Journal:  Protein Cell       Date:  2011-02-20       Impact factor: 14.870

3.  The Caenorhabditis elegans HNF4alpha Homolog, NHR-31, mediates excretory tube growth and function through coordinate regulation of the vacuolar ATPase.

Authors:  Annett Hahn-Windgassen; Marc R Van Gilst
Journal:  PLoS Genet       Date:  2009-07-10       Impact factor: 5.917

4.  The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis.

Authors:  Yujie Li; Qing Wei; Yuxia Zhang; Kun Ling; Jinghua Hu
Journal:  J Cell Biol       Date:  2010-06-07       Impact factor: 10.539

5.  ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice.

Authors:  Carlo Spirli; Stefano Okolicsanyi; Romina Fiorotto; Luca Fabris; Massimiliano Cadamuro; Silvia Lecchi; Xin Tian; Stefan Somlo; Mario Strazzabosco
Journal:  Gastroenterology       Date:  2009-09-18       Impact factor: 22.682

6.  Casein kinase II and calcineurin modulate TRPP function and ciliary localization.

Authors:  Jinghua Hu; Young-Kyung Bae; Karla M Knobel; Maureen M Barr
Journal:  Mol Biol Cell       Date:  2006-02-15       Impact factor: 4.138

Review 7.  Sensory roles of neuronal cilia: cilia development, morphogenesis, and function in C. elegans.

Authors:  Young-Kyung Bae; Maureen M Barr
Journal:  Front Biosci       Date:  2008-05-01

8.  STAM and Hrs down-regulate ciliary TRP receptors.

Authors:  Jinghua Hu; Samuel G Wittekind; Maureen M Barr
Journal:  Mol Biol Cell       Date:  2007-06-20       Impact factor: 4.138

Review 9.  Molecular anatomy of the kidney: what have we learned from gene expression and functional genomics?

Authors:  Bree Rumballe; Kylie Georgas; Lorine Wilkinson; Melissa Little
Journal:  Pediatr Nephrol       Date:  2010-01-05       Impact factor: 3.714

10.  Xenopus Bicaudal-C is required for the differentiation of the amphibian pronephros.

Authors:  Uyen Tran; L Mary Pickney; B Duygu Ozpolat; Oliver Wessely
Journal:  Dev Biol       Date:  2007-05-01       Impact factor: 3.582
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