| Literature DB >> 15894268 |
Conor C Lynch1, Atsuya Hikosaka, Heath B Acuff, Michelle D Martin, Noriyasu Kawai, Rakesh K Singh, Tracy C Vargo-Gogola, Jennifer L Begtrup, Todd E Peterson, Barbara Fingleton, Tomoyuki Shirai, Lynn M Matrisian, Mitsuru Futakuchi.
Abstract
We developed a rodent model that mimics the osteoblastic and osteolytic changes associated with human metastatic prostate cancer. Microarray analysis identified MMP-7, cathepsin-K, and apolipoprotein D as being upregulated at the tumor-bone interface. MMP-7, which was produced by osteoclasts at the tumor-bone interface, was capable of processing RANKL to a soluble form that promoted osteoclast activation. MMP-7-deficient mice demonstrated reduced prostate tumor-induced osteolysis and RANKL processing. This study suggests that inhibition of MMP-7 will have therapeutic benefit in the treatment of prostate cancer-induced osteolysis.Entities:
Mesh：
Substances：
Year: 2005 PMID： 15894268 DOI： 10.1016/j.ccr.2005.04.013
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743