| Literature DB >> 15893816 |
Leslie Y Yeo1, Zachary Gagnon, Hsueh-Chia Chang.
Abstract
A rapid, viable and safe fabrication method for biomaterials synthesis is reported using high-frequency AC electrospraying. We demonstrate its potential for polymeric nanoparticle fabrication, drug encapsulation in mono-dispersed micron-sized biodegradable polymer shells and the synthesis of 1microm biodegradable fibers with adjustable pore sizes as bioscaffolds for tissue/orthopaedic engineering and wound care therapy. The absence of charge in the ejected drops and fibers facilitates pulmonary drug delivery, polymer encapsulation and minimizes protein/DNA denaturing or compound ionization.Entities:
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Year: 2005 PMID： 15893816 DOI： 10.1016/j.biomaterials.2005.03.033
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479