Literature DB >> 15888308

Phosphoryl transfer by aminoglycoside 3'-phosphotransferases and manifestation of antibiotic resistance.

Choonkeun Kim1, Shahriar Mobashery.   

Abstract

Transfer of the gamma-phosphoryl group from ATP to aminoglycoside antibiotics by aminoglycoside 3'-phosphotransferases is one of the most important reactions for manifestation of bacterial resistance to this class of antibiotics. This review article surveys the latest structural and mechanistic findings with these enzymes.

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Year:  2004        PMID： 15888308     DOI： 10.1016/j.bioorg.2004.11.001

Source DB:  PubMed          Journal:  Bioorg Chem        ISSN： 0045-2068            Impact factor:   5.275


  13 in total

1.  Aminoglycoside 2''-phosphotransferase IIIa (APH(2'')-IIIa) prefers GTP over ATP: structural templates for nucleotide recognition in the bacterial aminoglycoside-2'' kinases.

Authors:  Clyde A Smith; Marta Toth; Hilary Frase; Laura J Byrnes; Sergei B Vakulenko
Journal:  J Biol Chem       Date:  2012-02-24       Impact factor: 5.157

2.  Overexpression and initial characterization of the chromosomal aminoglycoside 3'-O-phosphotransferase APH(3')-IIb from Pseudomonas aeruginosa.

Authors:  Mariana Hainrichson; Orit Yaniv; Marina Cherniavsky; Igor Nudelman; Dalia Shallom-Shezifi; Sima Yaron; Timor Baasov
Journal:  Antimicrob Agents Chemother       Date:  2006-11-06       Impact factor: 5.191

3.  Purification, crystallization and preliminary X-ray analysis of aminoglycoside-2''-phosphotransferase-Ic [APH(2'')-Ic] from Enterococcus gallinarum.

Authors:  Laura J Byrnes; Adriana Badarau; Sergei B Vakulenko; Clyde A Smith
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-01-31

4.  Using comparative genomics to uncover new kinds of protein-based metabolic organelles in bacteria.

Authors:  Julien Jorda; David Lopez; Nicole M Wheatley; Todd O Yeates
Journal:  Protein Sci       Date:  2013-01-04       Impact factor: 6.725

5.  Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia revealed by crystallographic and small-angle X-ray scattering analysis.

Authors:  Clyde A Smith; Marta Toth; Thomas M Weiss; Hilary Frase; Sergei B Vakulenko
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2014-09-27

Review 6.  Aminoglycosides: An Overview.

Authors:  Kevin M Krause; Alisa W Serio; Timothy R Kane; Lynn E Connolly
Journal:  Cold Spring Harb Perspect Med       Date:  2016-06-01       Impact factor: 6.915

7.  Purification, crystallization and preliminary X-ray analysis of the aminoglycoside-6'-acetyltransferase AAC(6')-Im.

Authors:  Marta Toth; Sergei B Vakulenko; Clyde A Smith
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2012-03-28

8.  Nucleoside triphosphate cosubstrates control the substrate profile and efficiency of aminoglycoside 3'-O-phosphotransferase type IIa.

Authors:  Selina Y L Holbrook; Matthew S Gentry; Oleg V Tsodikov; Sylvie Garneau-Tsodikova
Journal:  Medchemcomm       Date:  2018-07-16       Impact factor: 3.597

9.  The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily.

Authors:  Paul G Young; Rupa Walanj; Vendula Lakshmi; Laura J Byrnes; Peter Metcalf; Edward N Baker; Sergei B Vakulenko; Clyde A Smith
Journal:  J Bacteriol       Date:  2009-05-08       Impact factor: 3.490

10.  Structure of the phosphotransferase domain of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia.

Authors:  Clyde A Smith; Marta Toth; Monolekha Bhattacharya; Hilary Frase; Sergei B Vakulenko
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2014-05-23
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