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Literature DB >> 15886323

Wnts induce migration and invasion of myeloma plasma cells.

Ya-Wei Qiang¹, Katie Walsh, Lei Yao, Noemi Kedei, Peter M Blumberg, Jeffrey S Rubin, John Shaughnessy, Stuart Rudikoff.

Abstract

Multiple myeloma is an incurable form of lymphoid cancer characterized by accumulation of neoplastic plasma cells in the bone marrow cavity. Little is known about the mechanisms regulating myeloma cell movement within the bone marrow and metastasis to secondary sites. Herein, we identify multiple members of the wingless/int (Wnt) family as promoters of myeloma cell migration/invasion. Wnt-mediated migration was associated with the Wnt/RhoA pathway and did not necessitate signaling through beta-catenin. Activation of both RhoA and members of the protein kinase C (PKC) family, including PKCalpha, PKCbeta, and PKCmu, were required for induction of migration. Activated RhoA and PKCalpha, PKCbeta, and PKCmu appear to assemble in macromolecular signaling complexes that are associated with the cell membrane. These results suggest that Wnt responsiveness of myeloma plasma cells may be a significant factor in disease progression.

Entities: Disease Gene

Mesh：

Substances：

Year: 2005 PMID： 15886323 PMCID： PMC1895227 DOI： 10.1182/blood-2005-01-0049

Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113

55 in total

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