Literature DB >> 11918087

Monocyte chemoattractant protein-1 (MCP-1), secreted by bone marrow endothelial cells, induces chemoattraction of 5T multiple myeloma cells.

Karin Vanderkerken1, Isabelle Vande Broek, Décio L Eizirik, Els Van Valckenborgh, Kewal Asosingh, Ivan Van Riet, Ben Van Camp.   

Abstract

Homing of multiple myeloma (MM) cells to the bone marrow (BM) requires transendothelial migration. In the present work we tested whether monocyte chemoattractant protein-1 (MCP-1) and CCR2, the high affinity receptor for MCP-1, are involved in this process. Murine 5T2 and 5T33MM cell lines were selected as source of MM cells and STR4, 10 and 12 of BM endothelial cells (BMEC). RT-PCR demonstrated transcripts for MCP-1 in BMEC and ELISA the presence of MCP-1 protein in culture medium. RNase protection assay showed mRNA expression for CCR2, and FACS analysis the presence of CCR2 protein on the MM cells. EC conditioned medium induced chemoattraction of MM cells, a phenomenon inhibited by anti-MCP-1 antibodies. In conclusion, MM cells express CCR2 and are attracted by MCP-1 secreted by BMEC. We suggest that local MCP-1 production by BMEC is one of the mechanisms involved in homing of myeloma cells to the BM.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11918087     DOI： 10.1023/a:1013891205989

Source DB:  PubMed          Journal:  Clin Exp Metastasis        ISSN： 0262-0898            Impact factor:   5.150


  13 in total

Review 1.  The 5TMM series: a useful in vivo mouse model of human multiple myeloma.

Authors:  K Asosingh; J Radl; I Van Riet; B Van Camp; K Vanderkerken
Journal:  Hematol J       Date:  2000

2.  Insulin-like growth factor-1 acts as a chemoattractant factor for 5T2 multiple myeloma cells.

Authors:  K Vanderkerken; K Asosingh; F Braet; I Van Riet; B Van Camp
Journal:  Blood       Date:  1999-01-01       Impact factor: 22.113

3.  Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cells.

Authors:  J M Frade; M Mellado; G del Real; J C Gutierrez-Ramos; P Lind; C Martinez-A
Journal:  J Immunol       Date:  1997-12-01       Impact factor: 5.422

Review 4.  Lymphocyte homing and homeostasis.

Authors:  E C Butcher; L J Picker
Journal:  Science       Date:  1996-04-05       Impact factor: 47.728

5.  Identification of IL-1beta-induced messenger RNAs in rat pancreatic beta cells by differential display of messenger RNA.

Authors:  M C Chen; F Schuit; D L Eizirik
Journal:  Diabetologia       Date:  1999-10       Impact factor: 10.122

6.  Transendothelial migration of CD34+ and mature hematopoietic cells: an in vitro study using a human bone marrow endothelial cell line.

Authors:  R Möhle; M A Moore; R L Nachman; S Rafii
Journal:  Blood       Date:  1997-01-01       Impact factor: 22.113

Review 7.  Human monocyte chemoattractant protein-1 (MCP-1).

Authors:  E J Leonard; T Yoshimura
Journal:  Immunol Today       Date:  1990-03

8.  Monocyte chemotactic and activating factor gene expression induced in endothelial cells by IL-1 and tumor necrosis factor.

Authors:  A Sica; J M Wang; F Colotta; E Dejana; A Mantovani; J J Oppenheim; C G Larsen; C O Zachariae; K Matsushima
Journal:  J Immunol       Date:  1990-04-15       Impact factor: 5.422

9.  Organ involvement and phenotypic adhesion profile of 5T2 and 5T33 myeloma cells in the C57BL/KaLwRij mouse.

Authors:  K Vanderkerken; H De Raeve; E Goes; S Van Meirvenne; J Radl; I Van Riet; K Thielemans; B Van Camp
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

10.  Selective initial in vivo homing pattern of 5T2 multiple myeloma cells in the C57BL/KalwRij mouse.

Authors:  K Vanderkerken; C De Greef; K Asosingh; B Arteta; M De Veerman; I Vande Broek; I Van Riet; M Kobayashi; B Smedsrod; B Van Camp
Journal:  Br J Cancer       Date:  2000-02       Impact factor: 7.640
View more
  20 in total

Review 1.  Targeting chemokine (C-C motif) ligand 2 (CCL2) as an example of translation of cancer molecular biology to the clinic.

Authors:  Jian Zhang; Lalit Patel; Kenneth J Pienta
Journal:  Prog Mol Biol Transl Sci       Date:  2010       Impact factor: 3.622

2.  Osteoclast-gene expression profiling reveals osteoclast-derived CCR2 chemokines promoting myeloma cell migration.

Authors:  Jerome Moreaux; Dirk Hose; Alboukadel Kassambara; Thierry Reme; Philippe Moine; Guilhem Requirand; Hartmut Goldschmidt; Bernard Klein
Journal:  Blood       Date:  2010-11-19       Impact factor: 22.113

3.  Wnts induce migration and invasion of myeloma plasma cells.

Authors:  Ya-Wei Qiang; Katie Walsh; Lei Yao; Noemi Kedei; Peter M Blumberg; Jeffrey S Rubin; John Shaughnessy; Stuart Rudikoff
Journal:  Blood       Date:  2005-05-10       Impact factor: 22.113

Review 4.  Multiple roles of chemokine (C-C motif) ligand 2 in promoting prostate cancer growth.

Authors:  Jian Zhang; Yi Lu; Kenneth J Pienta
Journal:  J Natl Cancer Inst       Date:  2010-03-16       Impact factor: 13.506

5.  Macrophage chemotactic protein-1 mRNA levels in non-Hodgkin lymphoma.

Authors:  Toni Valković; Antica Duletić-Načinović; Sanja Stifter; Milena Hasan; Ita Hadžisejdić; David Zombori; Blaženka Grahovac; Nives Jonjić
Journal:  Clin Exp Med       Date:  2010-03-16       Impact factor: 3.984

6.  CCL2 as an important mediator of prostate cancer growth in vivo through the regulation of macrophage infiltration.

Authors:  Robert D Loberg; Chi Ying; Matt Craig; Li Yan; Linda A Snyder; Kenneth J Pienta
Journal:  Neoplasia       Date:  2007-07       Impact factor: 5.715

Review 7.  CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis.

Authors:  Jian Zhang; Lalit Patel; Kenneth J Pienta
Journal:  Cytokine Growth Factor Rev       Date:  2009-12-14       Impact factor: 7.638

8.  Chemokines, chemokine receptors and adhesion molecules on different human endothelia: discriminating the tissue-specific functions that affect leucocyte migration.

Authors:  P Hillyer; E Mordelet; G Flynn; D Male
Journal:  Clin Exp Immunol       Date:  2003-12       Impact factor: 4.330

9.  Mechanisms involved in the differential bone marrow homing of CD45 subsets in 5T murine models of myeloma.

Authors:  Kewal Asosingh; Eline Menu; Els Van Valckenborgh; Isabelle Vande Broek; Ivan Van Riet; Ben Van Camp; Karin Vanderkerken
Journal:  Clin Exp Metastasis       Date:  2002       Impact factor: 5.150

10.  Part of the multiple myeloma-associated microvessels is functionally connected to the systemic circulation: a study in the murine 5T33MM model.

Authors:  Hendrik R De Raeve; Kewal Asosingh; Eddie Wisse; Ben Van Camp; Eric Van Marck; Karin Vanderkerken
Journal:  Virchows Arch       Date:  2004-06-30       Impact factor: 4.064
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.