BACKGROUND: The psychopathology that manifests during the prodromal phase of first-episode psychosis is varied. Little is known about the clinical diagnoses of subjects with so-called prodromal or psychotic-like symptoms. METHOD: Samples of psychotic patients, first-degree relatives (FDRs) of psychotic, or severely ill patients, treatment-seeking patients, and a random community sample (in all 157 subjects) were assessed by the Structured Interview for Prodromal Symptoms (SIPS) and the SCID-I. Vulnerability to psychosis (VTP) was defined by severity of positive symptoms reported in the SIPS interview and associated with lifetime SCID-I diagnoses. RESULTS: The number of lifetime diagnoses received increased linearly as the SIPS symptoms approached more psychotic-like phenomena. All VTP subjects received on average 2.5, and currently prodromal subjects 2.9 lifetime SCID-I diagnoses, while the corresponding figure for non-VTP subjects was 0.7 (p<0.0001). Mood disorders and comorbid anxiety disorders were particularly common. CONCLUSION: Vulnerability to psychosis seems to be associated with a high number of lifetime Axis-I diagnoses. Occurrence of anxiety disorders is remarkable, and most VTP subjects can be diagnosed with a lifetime mood disorder. VTP subjects require careful assessment of mood and anxiety symptoms and adequate treatment for their multiple disorders.
BACKGROUND: The psychopathology that manifests during the prodromal phase of first-episode psychosis is varied. Little is known about the clinical diagnoses of subjects with so-called prodromal or psychotic-like symptoms. METHOD: Samples of psychoticpatients, first-degree relatives (FDRs) of psychotic, or severely ill patients, treatment-seeking patients, and a random community sample (in all 157 subjects) were assessed by the Structured Interview for Prodromal Symptoms (SIPS) and the SCID-I. Vulnerability to psychosis (VTP) was defined by severity of positive symptoms reported in the SIPS interview and associated with lifetime SCID-I diagnoses. RESULTS: The number of lifetime diagnoses received increased linearly as the SIPS symptoms approached more psychotic-like phenomena. All VTP subjects received on average 2.5, and currently prodromal subjects 2.9 lifetime SCID-I diagnoses, while the corresponding figure for non-VTP subjects was 0.7 (p<0.0001). Mood disorders and comorbid anxiety disorders were particularly common. CONCLUSION: Vulnerability to psychosis seems to be associated with a high number of lifetime Axis-I diagnoses. Occurrence of anxiety disorders is remarkable, and most VTP subjects can be diagnosed with a lifetime mood disorder. VTP subjects require careful assessment of mood and anxiety symptoms and adequate treatment for their multiple disorders.
Authors: Ian Kelleher; Aileen Murtagh; Charlene Molloy; Sarah Roddy; Mary C Clarke; Michelle Harley; Mary Cannon Journal: Schizophr Bull Date: 2011-11-17 Impact factor: 9.306
Authors: Jadon R Webb; Jean Addington; Diana O Perkins; Carrie E Bearden; Kristin S Cadenhead; Tyrone D Cannon; Barbara A Cornblatt; Robert K Heinssen; Larry J Seidman; Sarah I Tarbox; Ming T Tsuang; Elaine F Walker; Thomas H McGlashan; Scott W Woods Journal: Schizophr Bull Date: 2015-09 Impact factor: 9.306
Authors: Judith Rietdijk; Marjolein Fokkema; Daniel Stahl; Lucia Valmaggia; Helga K Ising; Sara Dragt; Rianne M C Klaassen; Dorien H Nieman; Rachel Loewy; Pim Cuijpers; Philippe Delespaul; Don H Linszen; Mark van der Gaag Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2013-10-15 Impact factor: 4.328
Authors: Jessica R Lunsford-Avery; Bruno da Silva Brandão Gonçalves; Elisa Brietzke; Rodrigo A Bressan; Ary Gadelha; Randy P Auerbach; Vijay A Mittal Journal: Schizophr Res Date: 2017-02-04 Impact factor: 4.939
Authors: Alice Masillo; M Brandizzi; L R Valmaggia; R Saba; N Lo Cascio; J F Lindau; L Telesforo; P Venturini; D Montanaro; D Di Pietro; M D'Alema; P Girardi; P Fiori Nastro Journal: Eur Child Adolesc Psychiatry Date: 2017-09-16 Impact factor: 4.785
Authors: Jessica R Lunsford-Avery; Joseph M Orr; Tina Gupta; Andrea Pelletier-Baldelli; Derek J Dean; Ashley K Smith Watts; Jessica Bernard; Zachary B Millman; Vijay A Mittal Journal: Schizophr Res Date: 2013-10-04 Impact factor: 4.939
Authors: Scott W Woods; Jean Addington; Kristin S Cadenhead; Tyrone D Cannon; Barbara A Cornblatt; Robert Heinssen; Diana O Perkins; Larry J Seidman; Ming T Tsuang; Elaine F Walker; Thomas H McGlashan Journal: Schizophr Bull Date: 2009-04-21 Impact factor: 9.306