| Literature DB >> 15882524 |
Ali Khamesipour1, Yahya Dowlati, Ali Asilian, Reza Hashemi-Fesharki, Amir Javadi, Sassan Noazin, Farrokh Modabber.
Abstract
To establish the safety and reproducibility of live challenge with Leishmania major, a single frozen stabilate was used in two open, single-arm leishmanization (LZ) trials. A total of 42 inoculations in 28 male adult volunteers were followed until complete healing. Lesions induced by LZ are as diverse as natural infection, but much milder. Total protection was seen in 100% (11/11) of recovered volunteers. LZ used as live challenge to test vaccine candidates reduces the required sample size, is cost effective for surrogate markers studies and will induce protection in the participants who are not protected by candidate vaccines.Entities:
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Year: 2005 PMID： 15882524 DOI： 10.1016/j.vaccine.2005.02.015
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641