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Literature DB >> 15880659

Identification of novel anthrax lethal factor inhibitors generated by combinatorial Pictet-Spengler reaction followed by screening in situ.

Mehdi M D Numa¹, Lac V Lee, Che-Chang Hsu, Kristen E Bower, Chi-Huey Wong.

Abstract

Entities: Species

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Year: 2005 PMID： 15880659 DOI： 10.1002/cbic.200500009

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

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13 in total

1. Polyvalent inhibitors of anthrax toxin that target host receptors.

Authors: Saleem Basha; Prakash Rai; Vincent Poon; Arundhati Saraph; Kunal Gujraty; Mandy Y Go; Skanda Sadacharan; Mia Frost; Jeremy Mogridge; Ravi S Kane
Journal: Proc Natl Acad Sci U S A Date: 2006-08-28 Impact factor: 11.205

2. Thioamide hydroxypyrothiones supersede amide hydroxypyrothiones in potency against anthrax lethal factor.

Authors: Arpita Agrawal; César Augusto F de Oliveira; Yuhui Cheng; Jennifer A Jacobsen; J Andrew McCammon; Seth M Cohen
Journal: J Med Chem Date: 2009-02-26 Impact factor: 7.446

3. New trends in aminoglycosides use.

Authors: Marina Y Fosso; Yijia Li; Sylvie Garneau-Tsodikova
Journal: Medchemcomm Date: 2014-08-01 Impact factor: 3.597

4. Structure-based design of a heptavalent anthrax toxin inhibitor.

Authors: Amit Joshi; Sandesh Kate; Vincent Poon; Dhananjoy Mondal; Mohan B Boggara; Arundhati Saraph; Jacob T Martin; Ryan McAlpine; Ryan Day; Angel E Garcia; Jeremy Mogridge; Ravi S Kane
Journal: Biomacromolecules Date: 2011-02-08 Impact factor: 6.988

5. Development of a comprehensive, validated pharmacophore hypothesis for anthrax toxin lethal factor (LF) inhibitors using genetic algorithms, Pareto scoring, and structural biology.

Authors: Ting-Lan Chiu; Elizabeth A Amin
Journal: J Chem Inf Model Date: 2012-06-25 Impact factor: 4.956

Identification of novel anthrax lethal factor inhibitors generated by combinatorial Pictet-Spengler reaction followed by screening in situ.

1. Polyvalent inhibitors of anthrax toxin that target host receptors.

2. Thioamide hydroxypyrothiones supersede amide hydroxypyrothiones in potency against anthrax lethal factor.

3. New trends in aminoglycosides use.

4. Structure-based design of a heptavalent anthrax toxin inhibitor.

5. Development of a comprehensive, validated pharmacophore hypothesis for anthrax toxin lethal factor (LF) inhibitors using genetic algorithms, Pareto scoring, and structural biology.

6. Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening.

7. Chelator fragment libraries for targeting metalloproteinases.

8. Highly predictive support vector machine (SVM) models for anthrax toxin lethal factor (LF) inhibitors.

9. Structure-activity relationship studies of a novel series of anthrax lethal factor inhibitors.

10. Inhibition of anthrax lethal factor by curcumin and chemically modified curcumin derivatives.