| Literature DB >> 15878277 |
Guangxin Xia1, Jianfeng Li, Aiming Peng, Shunan Lai, Shujun Zhang, Jingshan Shen, Zhonghua Liu, Xinjian Chen, Ruyun Ji.
Abstract
Synthesis and primary SAR of a novel series of 2-phenylpyrido[1,2-e]purin-4(3H)-one derivatives with piperazinyl sulfonamide substituents were described herein. As potential PDE5 inhibitors for erectile dysfunction (ED) treatment, representative compounds exhibit improved selectivity versus PDE1 and PDE6. Meanwhile, compound 3e demonstrated functional efficacy on rabbit corpus cavernosum strip in vitro.Entities:
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Year: 2005 PMID： 15878277 DOI： 10.1016/j.bmcl.2005.03.102
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823