Peter Meisel1, Thomas Kocher. 1. Department of Pharmacology, Ernst Moritz Arndt University Greifswald, F-Loeffler-Str. 23d, D-17487 Greifswald, Germany. meiselp@uni-greifswald.de
Abstract
BACKGROUND: Photodynamic killing of periodontopathogenic bacteria may be an alternative to the systemic application of antibacterial drugs used in the treatment of periodontal diseases. Even though the method is still in the experimental stage, increasing bacterial resistance problems may promote the introduction of photodynamic therapy (PDT) into periodontal practice. AIM: In this review a literature survey is given of PDT as seen from a periodontal perspective. METHODS: In this review, the present knowledge and experience of PDT is summarized. Literature data are presented on drawbacks of conventional antibiotics, the mechanism of PDT, bactericidal effects of PDT as well as results of clinical efforts. The future prospects of the method are discussed. RESULTS: The application of photosensitizing dyes and their excitation by visible light enables effective killing of periodontopathogens. Encouraging studies using PDT in periodontitis and in peri-implantitis are known. CONCLUSION: Even though PDT is still in experimental stages of development and testing, the method may be an adjunct to conventional antibacterial measures in periodontology. Clinical follow-up studies are needed to confirm the efficacy of the procedure.
BACKGROUND: Photodynamic killing of periodontopathogenic bacteria may be an alternative to the systemic application of antibacterial drugs used in the treatment of periodontal diseases. Even though the method is still in the experimental stage, increasing bacterial resistance problems may promote the introduction of photodynamic therapy (PDT) into periodontal practice. AIM: In this review a literature survey is given of PDT as seen from a periodontal perspective. METHODS: In this review, the present knowledge and experience of PDT is summarized. Literature data are presented on drawbacks of conventional antibiotics, the mechanism of PDT, bactericidal effects of PDT as well as results of clinical efforts. The future prospects of the method are discussed. RESULTS: The application of photosensitizing dyes and their excitation by visible light enables effective killing of periodontopathogens. Encouraging studies using PDT in periodontitis and in peri-implantitis are known. CONCLUSION: Even though PDT is still in experimental stages of development and testing, the method may be an adjunct to conventional antibacterial measures in periodontology. Clinical follow-up studies are needed to confirm the efficacy of the procedure.
Authors: Martin Schneider; Gregor Kirfel; Michael Berthold; Matthias Frentzen; Felix Krause; Andreas Braun Journal: Lasers Med Sci Date: 2011-10-02 Impact factor: 3.161
Authors: Carlos de Paula Eduardo; Patricia Moreira de Freitas; Marcella Esteves-Oliveira; Ana Cecília Corrêa Aranha; Karen Müller Ramalho; Alyne Simões; Marina Stella Bello-Silva; Jan Tunér Journal: Lasers Med Sci Date: 2010-07-17 Impact factor: 3.161
Authors: Aguinaldo S Garcez; Martha S Ribeiro; George P Tegos; Silvia C Núñez; Antonio O C Jorge; Michael R Hamblin Journal: Lasers Surg Med Date: 2007-01 Impact factor: 4.025
Authors: Fernando Luis Esteban Florez; Rochelle Denise Hiers; Preston Larson; Matthew Johnson; Edgar O'Rear; Adam J Rondinone; Sharukh Soli Khajotia Journal: Mater Sci Eng C Mater Biol Appl Date: 2018-09-01 Impact factor: 7.328
Authors: Luciana S A de Melo; Anderson S L Gomes; Sybele Saska; Karina Nigoghossian; Younes Messaddeq; Sidney J L Ribeiro; Renato E de Araujo Journal: J Fluoresc Date: 2012-07-28 Impact factor: 2.217