| Literature DB >> 15878008 |
Julio A Chirinos1, Juan P Zambrano, Salim S Virani, Joaquin J Jimenez, Wenche Jy, Eugene Ahn, Lawrence L Horstman, Agustin Castellanos, Robert J Myerburg, Yeon S Ahn.
Abstract
Inflammation has been associated with increased cardiovascular risk, and endothelial cell (EC) apoptosis has been implicated in atherogenesis. The correlation between circulating concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and endothelial microparticles (EMPs) expressing an apoptotic (EMP31) or activation (EMP62E) phenotype in 20 middle-aged healthy men was investigated. IL-6 was significantly correlated with EMP31 (r = 0.6, p = 0.004), which persisted after adjusting for body mass index and CRP. CRP was significantly correlated with body mass index (r = 0.49, p = 0.02) but not with EMP31 or EMP62E. EC apoptosis is associated with IL-6 levels in men and might be partially responsible for the increased cardiovascular risk associated with subclinical inflammation.Entities:
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Year: 2005 PMID： 15878008 DOI： 10.1016/j.amjcard.2005.01.063
Source DB: PubMed Journal: Am J Cardiol ISSN： 0002-9149 Impact factor: 2.778