| Literature DB >> 23892447 |
Anne M Curtis1, Jay Edelberg, Rebecca Jonas, Wade T Rogers, Jonni S Moore, Wajihuddin Syed, Emile R Mohler.
Abstract
Endothelial microparticles (EMPs) belong to a family of extracellular vesicles that are dynamic, mobile, biological effectors capable of mediating vascular physiology and function. The release of EMPs can impart autocrine and paracrine effects on target cells through surface interaction, cellular fusion, and, possibly, the delivery of intra-vesicular cargo. A greater understanding of the formation, composition, and function of EMPs will broaden our understanding of endothelial communication and may expose new pathways amenable for therapeutic manipulation.Entities:
Keywords: endothelial dysfunction; endothelial microparticles; therapeutics; vesiculation
Mesh:
Year: 2013 PMID: 23892447 PMCID: PMC4437568 DOI: 10.1177/1358863X13499773
Source DB: PubMed Journal: Vasc Med ISSN: 1358-863X Impact factor: 3.239