| Literature DB >> 15877477 |
Ian R Baxendale1, Steven V Ley.
Abstract
A series of substituted aliphatic nitriles have been trimerized to their corresponding pyrimidine structures under solvent-free conditions in the presence of catalytic quantities of potassium tert-butoxide using a focused microwave reactor. Multigram quantities of the corresponding 4-aminopyrimidines have been prepared in high yields and purity following a simple and scaleable protocol.Entities:
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Year: 2005 PMID： 15877477 DOI： 10.1021/cc049826d
Source DB: PubMed Journal: J Comb Chem ISSN： 1520-4766