PURPOSE: Ultrasound biomicroscopy (UBM) can noninvasively provide anatomical information about mouse ocular structures. We present the quantitation of postnatal murine eye development using UBM. MATERIALS AND METHODS: The eyes from CD-1 mice were examined at 1, 2, 4, 6, and 8 weeks of postnatal development using 40 MHz UBM. Patterns of ocular tissue growth including the lens, globe, and anterior chamber were calculated. RESULTS: Postnatal CD-1 lens and globe volumes are consistent with an exponential decay of growth during the first 8 postnatal weeks. Anterior chamber depth increases most sharply in the first 2 postnatal weeks but continues to increase up to the 8th postnatal week. Anterior segment angle was observed to increase from 1 to 4 weeks. CONCLUSIONS: UBM can be used to obtain in vivo quantitative measurements of postnatal murine ocular structures. Our ability to obtain ocular anatomical information will facilitate future assessments of mouse models of human disease.
PURPOSE: Ultrasound biomicroscopy (UBM) can noninvasively provide anatomical information about mouse ocular structures. We present the quantitation of postnatal murine eye development using UBM. MATERIALS AND METHODS: The eyes from CD-1mice were examined at 1, 2, 4, 6, and 8 weeks of postnatal development using 40 MHz UBM. Patterns of ocular tissue growth including the lens, globe, and anterior chamber were calculated. RESULTS: Postnatal CD-1 lens and globe volumes are consistent with an exponential decay of growth during the first 8 postnatal weeks. Anterior chamber depth increases most sharply in the first 2 postnatal weeks but continues to increase up to the 8th postnatal week. Anterior segment angle was observed to increase from 1 to 4 weeks. CONCLUSIONS: UBM can be used to obtain in vivo quantitative measurements of postnatal murine ocular structures. Our ability to obtain ocular anatomical information will facilitate future assessments of mouse models of human disease.
Authors: Tsung-Han Chou; Omer P Kocaoglu; David Borja; Marco Ruggeri; Stephen R Uhlhorn; Fabrice Manns; Vittorio Porciatti Journal: Invest Ophthalmol Vis Sci Date: 2011-06-01 Impact factor: 4.799
Authors: Emmanuel S Buys; Yu-Chieh Ko; Clemens Alt; Sarah R Hayton; Alexander Jones; Laurel T Tainsh; Ruiyi Ren; Andrea Giani; Maeva Clerté; Emma Abernathy; Robert E T Tainsh; Dong-Jin Oh; Rajeev Malhotra; Pankaj Arora; Nadine de Waard; Binglan Yu; Raphael Turcotte; Daniel Nathan; Marielle Scherrer-Crosbie; Stephanie J Loomis; Jae H Kang; Charles P Lin; Haiyan Gong; Douglas J Rhee; Peter Brouckaert; Janey L Wiggs; Meredith S Gregory; Louis R Pasquale; Kenneth D Bloch; Bruce R Ksander Journal: PLoS One Date: 2013-03-20 Impact factor: 3.240