| Literature DB >> 15869264 |
Simon J Shaw1, Kurt F Sundermann, Mark A Burlingame, David C Myles, B Scott Freeze, Ming Xian, Ignacio Brouard, Amos B Smith.
Abstract
A series of simplified discodermolide analogues have been designed and synthesized in an attempt to understand the role of the lactone ring. These synthetic efforts have led to an unsubstituted butyrolactone 9 being generated, which shows improved activity over the natural product.Entities:
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Year: 2005 PMID： 15869264 DOI： 10.1021/ja051185i
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419