| Literature DB >> 15866025 |
Vincent Vanoosthuyse1, Kevin G Hardwick.
Abstract
To ensure the accuracy of chromosome segregation in mitosis, the spindle checkpoint blocks the activity of the anaphase-promoting complex APC/C until all chromosomes are properly bi-orientated on the metaphase spindle. How the checkpoint machinery actually inhibits the APC/C is still unclear. A new paper by Tang and coworkers helps further our understanding of this complex and fundamental process.Entities:
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Year: 2005 PMID： 15866025 DOI： 10.1016/j.tcb.2005.03.003
Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808