Literature DB >> 15865934

Death squads enlisted by the tumour suppressor p53.

Ewa Michalak1, Andreas Villunger, Miriam Erlacher, Andreas Strasser.   

Abstract

p53 is a tumour suppressor that is found mutated or functionally inactivated in more than half of all human cancers. p53 function is activated by DNA damage, hypoxia, expression of certain oncogenes, and many cytotoxic stimuli. p53 is a transcription factor that regulates expression of target genes which promote apoptotic cell death, cell cycle arrest, cellular senescence, and some other processes. In this review we summarise current knowledge of p53 target genes implicated in apoptosis signalling.

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Year:  2005        PMID： 15865934     DOI： 10.1016/j.bbrc.2005.03.183

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  30 in total

1.  Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death.

Authors:  Panagiota A Sotiropoulou; Aurélie Candi; Guilhem Mascré; Sarah De Clercq; Khalil Kass Youssef; Gaelle Lapouge; Ellen Dahl; Claudio Semeraro; Geertrui Denecker; Jean-Christophe Marine; Cédric Blanpain
Journal:  Nat Cell Biol       Date:  2010-05-16       Impact factor: 28.824

2.  An inhibitor of the kinesin spindle protein activates the intrinsic apoptotic pathway independently of p53 and de novo protein synthesis.

Authors:  Weikang Tao; Victoria J South; Ronald E Diehl; Joseph P Davide; Laura Sepp-Lorenzino; Mark E Fraley; Kenneth L Arrington; Robert B Lobell
Journal:  Mol Cell Biol       Date:  2006-11-13       Impact factor: 4.272

3.  Context-dependent enhancement of induced pluripotent stem cell reprogramming by silencing Puma.

Authors:  Blue B Lake; Jürgen Fink; Liv Klemetsaune; Xuemei Fu; John R Jeffers; Gerard P Zambetti; Yang Xu
Journal:  Stem Cells       Date:  2012-05       Impact factor: 6.277

4.  Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.

Authors:  Claire M Payne; Cheray Crowley-Skillicorn; Carol Bernstein; Hana Holubec; Harris Bernstein
Journal:  Clin Exp Gastroenterol       Date:  2011-05-03

5.  Computational analysis of dynamical responses to the intrinsic pathway of programmed cell death.

Authors:  Tongli Zhang; Paul Brazhnik; John J Tyson
Journal:  Biophys J       Date:  2009-07-22       Impact factor: 4.033

6.  Puma is required for p53-induced depletion of adult stem cells.

Authors:  Dongping Liu; Linda Ou; Gregory D Clemenson; Connie Chao; Marshall Eli Lutske; Gerard P Zambetti; Fred H Gage; Yang Xu
Journal:  Nat Cell Biol       Date:  2010-09-05       Impact factor: 28.824

7.  High Frequency of p53/MDM2/p14ARF Pathway Abnormalities in Relapsed Neuroblastoma.

Authors:  Jane Carr-Wilkinson; Kieran O'Toole; Katrina M Wood; Christine C Challen; Angela G Baker; Julian R Board; Laura Evans; Michael Cole; Nai-Kong V Cheung; Joachim Boos; Gabriele Köhler; Ivo Leuschner; Andrew D J Pearson; John Lunec; Deborah A Tweddle
Journal:  Clin Cancer Res       Date:  2010-02-09       Impact factor: 12.531

8.  In the absence of Sonic hedgehog, p53 induces apoptosis and inhibits retinal cell proliferation, cell-cycle exit and differentiation in zebrafish.

Authors:  Sergey V Prykhozhij
Journal:  PLoS One       Date:  2010-10-21       Impact factor: 3.240

Review 9.  Oxidative stress and pulmonary fibrosis.

Authors:  Paul Cheresh; Seok-Jo Kim; Sandhya Tulasiram; David W Kamp
Journal:  Biochim Biophys Acta       Date:  2012-12-05

10.  Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo.

Authors:  Sarah Francoz; Pascal Froment; Sven Bogaerts; Sarah De Clercq; Marion Maetens; Gilles Doumont; Eric Bellefroid; Jean-Christophe Marine
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-21       Impact factor: 11.205
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