| Literature DB >> 15865210 |
Liu Wang1, Chaoneng Jil, Yiren Xu, Jian Xu, Jianfeng Dai, Qihan Wu, Maoqing Wu, Xianqiong Zou, Liyun Sun, Shaohua Gu, Yi Xie, Yumin Mao.
Abstract
Mouse U26 has been defined as a 2-aminoadipic 6-semialdehyde dehydrogenase. It was speculated to be a PQQ-dependent AAS dehydrogenase due to the research of demonstrating PQQ as a new B vitamin. We isolated a novel human cDNA from the human fetal brain cDNA library we constructed. Its deduced protein was most related to mouse U26. Thus, we termed it human U26. This putative protein contains an AMP-binding domain, a Phosphopantetheine-binding domain and six PQQ-binding motifs. Human U26 mRNA is ubiquitously expressed in adult tissues and is highly expressed in colon adenocarcinoma (CX-1) and colon adenocarcinoma (GI-112) cell lines. Further study should be made to clarify the precise function of human U26.Entities:
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Year: 2005 PMID： 15865210 DOI： 10.1007/s11033-003-2716-4
Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316