RATIONALE: We report on a cerebral infection by Pseudallescheria boydii in a 21-month-old boy after a near-drowning episode. MRI revealed multiple (> 60) intracerebral abscesses. METHODS: The surgical therapy included CSF drainage and microsurgical resection of one abscess for microbiological diagnosis. Antimycotic therapy included terbinafine and intraventricular caspofungin in addition to voriconazole. RESULTS: Systemic side effects of chemotherapy were not observed. After placement of a ventriculoperitoneal shunt, the boy was transferred to a rehabilitation clinic and improved neurologically. After 20 months, MRI documented a continuing remission of the disease. CONCLUSION: Our case proves that an aggressive treatment should be undertaken and can be successful in CNS pseudallescheriasis.
RATIONALE: We report on a cerebral infection by Pseudallescheria boydii in a 21-month-old boy after a near-drowning episode. MRI revealed multiple (> 60) intracerebral abscesses. METHODS: The surgical therapy included CSF drainage and microsurgical resection of one abscess for microbiological diagnosis. Antimycotic therapy included terbinafine and intraventricular caspofungin in addition to voriconazole. RESULTS: Systemic side effects of chemotherapy were not observed. After placement of a ventriculoperitoneal shunt, the boy was transferred to a rehabilitation clinic and improved neurologically. After 20 months, MRI documented a continuing remission of the disease. CONCLUSION: Our case proves that an aggressive treatment should be undertaken and can be successful in CNS pseudallescheriasis.
Authors: J F Fisher; S Shadomy; J R Teabeaut; J Woodward; G E Michaels; M A Newman; E White; P Cook; A Seagraves; F Yaghmai; J P Rissing Journal: Arch Neurol Date: 1982-08
Authors: P Kershaw; R Freeman; D Templeton; P C DeGirolami; U DeGirolami; D Tarsy; S Hoffmann; G Eliopoulos; A W Karchmer Journal: Arch Neurol Date: 1990-04
Authors: Peter Troke; Koldo Aguirrebengoa; Carmen Arteaga; David Ellis; Christopher H Heath; Irja Lutsar; Montserrat Rovira; Quoc Nguyen; Monica Slavin; Sharon C A Chen Journal: Antimicrob Agents Chemother Date: 2008-01-22 Impact factor: 5.191