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Literature DB >> 15864652

The Kavar(D) dominant female-sterile mutations of Drosophila reveal a role for the maternally provided alpha-tubulin4 isoform in cleavage spindle maintenance and elongation.

Abstract

The dominant-negative female-sterile Kavar(D) mutations and their revertant kavar(r) alleles identify the alphaTubulin67C gene of Drosophila melanogaster, which codes for the maternally provided alpha-tubulin(4) isoform. The mutations result in the formation of monopolar, collapsed spindles (each with two nearby centrosomes, a tassel of microtubules and overcondensed chromosomes), thus revealing a novel function for alpha-tubulin(4) in spindle maintenance and elongation. Molecular features of the two Kavar(D) alleles and a kavar(null) allele are described and models for their actions are discussed.

Entities: Gene Species

Mesh：

Substances：
Protein Isoforms
Tubulin

Year: 2005 PMID： 15864652 DOI： 10.1007/s00438-005-1109-x

Source DB: PubMed Journal: Mol Genet Genomics ISSN： 1617-4623 Impact factor: 3.291

28 in total

1. Functional coordination of three mitotic motors in Drosophila embryos.

Authors: D J Sharp; H M Brown; M Kwon; G C Rogers; G Holland; J M Scholey
Journal: Mol Biol Cell Date: 2000-01 Impact factor: 4.138

2. Microtubule structure at 8 A resolution.

Authors: Huilin Li; David J DeRosier; William V Nicholson; Eva Nogales; Kenneth H Downing
Journal: Structure Date: 2002-10 Impact factor: 5.006

3. Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase.

Authors: Gregory C Rogers; Stephen L Rogers; Tamara A Schwimmer; Stephanie C Ems-McClung; Claire E Walczak; Ronald D Vale; Jonathan M Scholey; David J Sharp
Journal: Nature Date: 2003-12-14 Impact factor: 49.962

4. Antagonistic microtubule-sliding motors position mitotic centrosomes in Drosophila early embryos.

Authors: D J Sharp; K R Yu; J C Sisson; W Sullivan; J M Scholey
Journal: Nat Cell Biol Date: 1999-05 Impact factor: 28.824

5. Tissue-specific and constitutive alpha-tubulin genes of Drosophila melanogaster code for structurally distinct proteins.

Authors: W E Theurkauf; H Baum; J Bo; P C Wensink
Journal: Proc Natl Acad Sci U S A Date: 1986-11 Impact factor: 11.205

6. Control of the structural stability of the tubulin dimer by one high affinity bound magnesium ion at nucleotide N-site.

Authors: M Menéndez; G Rivas; J F Díaz; J M Andreu
Journal: J Biol Chem Date: 1998-01-02 Impact factor: 5.157

2. αTubulin 67C and Ncd are essential for establishing a cortical microtubular network and formation of the Bicoid mRNA gradient in Drosophila.

Authors: Khalid Fahmy; Mira Akber; Xiaoli Cai; Aabid Koul; Awais Hayder; Stefan Baumgartner
Journal: PLoS One Date: 2014-11-12 Impact factor: 3.240

2 in total

The Kavar(D) dominant female-sterile mutations of Drosophila reveal a role for the maternally provided alpha-tubulin4 isoform in cleavage spindle maintenance and elongation.

1. Functional coordination of three mitotic motors in Drosophila embryos.

2. Microtubule structure at 8 A resolution.

3. Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase.

4. Antagonistic microtubule-sliding motors position mitotic centrosomes in Drosophila early embryos.

5. Tissue-specific and constitutive alpha-tubulin genes of Drosophila melanogaster code for structurally distinct proteins.

6. Control of the structural stability of the tubulin dimer by one high affinity bound magnesium ion at nucleotide N-site.

7. Cytoplasmic dynein is required for the nuclear attachment and migration of centrosomes during mitosis in Drosophila.

8. Mutations in the alpha-tubulin 67C gene specifically impair achiasmate segregation in Drosophila melanogaster.

9. A functionally specialized alpha-tubulin is required for oocyte meiosis and cleavage mitoses in Drosophila.

10. The kinesin-like protein KLP61F is essential for mitosis in Drosophila.

1. Inferring the distribution of mutational effects on fitness in Drosophila.

2. αTubulin 67C and Ncd are essential for establishing a cortical microtubular network and formation of the Bicoid mRNA gradient in Drosophila.