| Literature DB >> 15863319 |
Rômulo P Tenório1, Cristiane S Carvalho, Carla S Pessanha, José G de Lima, Antônio R de Faria, Antônio J Alves, Edésio J T de Melo, Alexandre J S Góes.
Abstract
Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively, from thiosemicarbazide, in satisfactory yields. Then, the synthesized compounds were submitted to evaluation against host cells infected with Toxoplasma gondii. The present studies showed that thiosemicarbazones 2 and 4-thiazolidinone derivatives 3 were effective against intracellular T. gondii.Entities:
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Year: 2005 PMID： 15863319 DOI： 10.1016/j.bmcl.2005.03.048
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823