Literature DB >> 15863305

Structure-based design of protein tyrosine phosphatase-1B inhibitors.

Emma Black1, Jason Breed, Alexander L Breeze, Kevin Embrey, Robert Garcia, Thomas W Gero, Linda Godfrey, Peter W Kenny, Andrew D Morley, Claire A Minshull, Andrew D Pannifer, Jon Read, Amanda Rees, Daniel J Russell, Dorin Toader, Julie Tucker.   

Abstract

Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15863305     DOI： 10.1016/j.bmcl.2005.03.068

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH.

Authors:  Marilisa Leone; Elisa Barile; Jesus Vazquez; Angel Mei; Donald Guiney; Russel Dahl; Maurizio Pellecchia
Journal:  Chem Biol Drug Des       Date:  2010-04-28       Impact factor: 2.817

2.  Design of compound libraries for fragment screening.

Authors:  Niklas Blomberg; David A Cosgrove; Peter W Kenny; Karin Kolmodin
Journal:  J Comput Aided Mol Des       Date:  2009-03-13       Impact factor: 3.686

3.  Ligand efficiency metrics considered harmful.

Authors:  Peter W Kenny; Andrei Leitão; Carlos A Montanari
Journal:  J Comput Aided Mol Des       Date:  2014-06-05       Impact factor: 3.686

Review 4.  Targeting PTPs with small molecule inhibitors in cancer treatment.

Authors:  Zhong-Xing Jiang; Zhong-Yin Zhang
Journal:  Cancer Metastasis Rev       Date:  2008-06       Impact factor: 9.264

5.  Crystal structure of 5-{4'-[(2-{2-[2-(2-ammonio-eth-oxy)eth-oxy]eth-oxy}eth-yl)carbamo-yl]-4-meth-oxy-[1,1'-biphen-yl]-3-yl}-3-oxo-1,2,5-thia-diazo-lidin-2-ide 1,1-dioxide: a potential inhibitor of the enzyme protein tyrosine phosphatase 1B (PTP1B).

Authors:  Kasi Viswanatharaju Ruddraraju; Roman Hillebrand; Charles L Barnes; Kent S Gates
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-03-04

6.  Novel Mixed-Type Inhibitors of Protein Tyrosine Phosphatase 1B. Kinetic and Computational Studies.

Authors:  Marie Jazmín Sarabia-Sánchez; Pedro Josué Trejo-Soto; José Miguel Velázquez-López; Carlos Carvente-García; Rafael Castillo; Alicia Hernández-Campos; Claudia Avitia-Domínguez; Daniel Enríquez-Mendiola; Erick Sierra-Campos; Mónica Valdez-Solana; José Manuel Salas-Pacheco; Alfredo Téllez-Valencia
Journal:  Molecules       Date:  2017-12-20       Impact factor: 4.411

Review 7.  Computational Methods in Cooperation with Experimental Approaches to Design Protein Tyrosine Phosphatase 1B Inhibitors in Type 2 Diabetes Drug Design: A Review of the Achievements of This Century.

Authors:  Mara Ibeth Campos-Almazán; Alicia Hernández-Campos; Rafael Castillo; Erick Sierra-Campos; Mónica Valdez-Solana; Claudia Avitia-Domínguez; Alfredo Téllez-Valencia
Journal:  Pharmaceuticals (Basel)       Date:  2022-07-14

8.  QSAR Study on a Series of Protein Tyrosine Phosphatase 1B Inhibitors.

Authors:  Rajendra S Mehta; Hetal R Prajapati; Dinesh V Thakkar; Pathik S Brahmkshatriya
Journal:  Int J Biomed Sci       Date:  2008-12
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.