OBJECTIVE: Frozen section is an important and helpful adjunct in the intraoperative diagnosis of ovarian tumors. This retrospective study was undertaken to determine the accuracy of frozen section diagnosis of ovarian masses and the reasons of discordance. METHODS: From January 1995 to December 2003, 1494 ovarian specimens were received for histopathological evaluation, and 617 of them were submitted for frozen section examination. RESULTS.: The final paraffin section diagnoses of these 617 cases were a nonneoplastic lesion in 18.3% of the cases, benign tumor in 56.1%, borderline tumor in 6.2%, and malignant tumor in 19.4%. The overall accuracy was 97%. Twenty-one cases were incorrectly diagnosed by frozen section. All of them were false negatives. There were no deferred cases. The majority of the cases of disagreement were mucinous and borderline tumors. The sensitivity for benign, borderline, and malignant tumors were 100%, 87%, and 87%, respectively. The specificity for benign tumors was 97%; for borderline tumors 98%; and for malignant tumors 100%. CONCLUSION: Our data confirm that frozen section diagnosis is a reliable method for the surgical management of patients with an ovarian mass. However, diagnostic problems can occur in mucinous and borderline tumors during frozen section examination. The clinicians and pathologists must be aware of the pitfalls of this method; therefore, a good communication established between them is necessary to obtain more accurate results and to minimize the number of deferred cases.
OBJECTIVE: Frozen section is an important and helpful adjunct in the intraoperative diagnosis of ovarian tumors. This retrospective study was undertaken to determine the accuracy of frozen section diagnosis of ovarian masses and the reasons of discordance. METHODS: From January 1995 to December 2003, 1494 ovarian specimens were received for histopathological evaluation, and 617 of them were submitted for frozen section examination. RESULTS.: The final paraffin section diagnoses of these 617 cases were a nonneoplastic lesion in 18.3% of the cases, benign tumor in 56.1%, borderline tumor in 6.2%, and malignant tumor in 19.4%. The overall accuracy was 97%. Twenty-one cases were incorrectly diagnosed by frozen section. All of them were false negatives. There were no deferred cases. The majority of the cases of disagreement were mucinous and borderline tumors. The sensitivity for benign, borderline, and malignant tumors were 100%, 87%, and 87%, respectively. The specificity for benign tumors was 97%; for borderline tumors 98%; and for malignant tumors 100%. CONCLUSION: Our data confirm that frozen section diagnosis is a reliable method for the surgical management of patients with an ovarian mass. However, diagnostic problems can occur in mucinous and borderline tumors during frozen section examination. The clinicians and pathologists must be aware of the pitfalls of this method; therefore, a good communication established between them is necessary to obtain more accurate results and to minimize the number of deferred cases.
Authors: Jaimin S Shah; Michael Mackelvie; David M Gershenson; Preetha Ramalingam; Marylee M Kott; Jubilee Brown; Polly Gauthier; Elizabeth Nugent; Lois M Ramondetta; Michael Frumovitz Journal: J Minim Invasive Gynecol Date: 2018-04-19 Impact factor: 4.137
Authors: Francesco Cosentino; Luigi Carlo Turco; Stefano Cianci; Francesco Fanfani; Anna Fagotti; Salvatore Gueli Alletti; Giuseppe Vizzielli; Salvatore Giovanni Vitale; Antonio Simone Laganà; Francesco Padula; Claudio Coco; Salvatore Pisconti; Giovanni Scambia Journal: J Prenat Med Date: 2016 Jan-Jun
Authors: Jin Hwi Kim; Tae Jung Kim; Yong Gyu Park; Sung Ha Lee; Chung Won Lee; Min Jong Song; Keun Ho Lee; Soo Young Hur; Seog Nyeon Bae; Jong Sup Park Journal: J Gynecol Oncol Date: 2009-09-30 Impact factor: 4.401
Authors: Nithya D G Ratnavelu; Andrew P Brown; Susan Mallett; Rob J P M Scholten; Amit Patel; Christina Founta; Khadra Galaal; Paul Cross; Raj Naik Journal: Cochrane Database Syst Rev Date: 2016-03-01