Literature DB >> 15863035

FGF signaling in the developing endochondral skeleton.

David M Ornitz1.   

Abstract

Mutations in fibroblast growth factor receptors (Fgfrs) are the etiology of many craniosynostosis and chondrodysplasia syndromes in humans. The phenotypes associated with these human syndromes and the phenotypes resulting from targeted mutagenesis in the mouse have defined essential roles for FGF signaling in both endochondral and intramembranous bone development. In this review, I will focus on the role of FGF signaling in chondrocytes and osteoblasts and how FGFs regulate the growth and development of endochondral bone.

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Year:  2005        PMID： 15863035      PMCID： PMC3083241          DOI： 10.1016/j.cytogfr.2005.02.003

Source DB:  PubMed          Journal:  Cytokine Growth Factor Rev        ISSN： 1359-6101            Impact factor:   7.638


  126 in total

1.  Fibroblast growth factor receptor 2 mutations in Beare-Stevenson cutis gyrata syndrome.

Authors:  K A Przylepa; W Paznekas; M Zhang; M Golabi; W Bias; M J Bamshad; J C Carey; B D Hall; R Stevenson; S Orlow; M M Cohen; E W Jabs
Journal:  Nat Genet       Date:  1996-08       Impact factor: 38.330

2.  A unique point mutation in the fibroblast growth factor receptor 3 gene (FGFR3) defines a new craniosynostosis syndrome.

Authors:  M Muenke; K W Gripp; D M McDonald-McGinn; K Gaudenz; L A Whitaker; S P Bartlett; R I Markowitz; N H Robin; N Nwokoro; J J Mulvihill; H W Losken; J B Mulliken; A E Guttmacher; R S Wilroy; L A Clarke; G Hollway; L C Adès; E A Haan; J C Mulley; M M Cohen; G A Bellus; C A Francomano; D M Moloney; S A Wall; A O Wilkie
Journal:  Am J Hum Genet       Date:  1997-03       Impact factor: 11.025

3.  Crouzon syndrome: previously unrecognized deletion, duplication, and point mutation within FGFR2 gene.

Authors:  D Steinberger; J B Mulliken; U Müller
Journal:  Hum Mutat       Date:  1996       Impact factor: 4.878

4.  A recurrent mutation, ala391glu, in the transmembrane region of FGFR3 causes Crouzon syndrome and acanthosis nigricans.

Authors:  D Wilkes; P Rutland; L J Pulleyn; W Reardon; C Moss; J P Ellis; R M Winter; S Malcolm
Journal:  J Med Genet       Date:  1996-09       Impact factor: 6.318

5.  The fibroblast growth factor receptor-1 is necessary for the induction of neurite outgrowth in PC12 cells by aFGF.

Authors:  H Y Lin; J Xu; D M Ornitz; S Halegoua; M J Hayman
Journal:  J Neurosci       Date:  1996-08-01       Impact factor: 6.167

6.  Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism.

Authors:  W C Su; M Kitagawa; N Xue; B Xie; S Garofalo; J Cho; C Deng; W A Horton; X Y Fu
Journal:  Nature       Date:  1997-03-20       Impact factor: 49.962

7.  FGFR2 exon IIIa and IIIc mutations in Crouzon, Jackson-Weiss, and Pfeiffer syndromes: evidence for missense changes, insertions, and a deletion due to alternative RNA splicing.

Authors:  G A Meyers; D Day; R Goldberg; D L Daentl; K A Przylepa; L J Abrams; J M Graham; M Feingold; J B Moeschler; E Rawnsley; A F Scott; E W Jabs
Journal:  Am J Hum Genet       Date:  1996-03       Impact factor: 11.025

8.  Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia.

Authors:  M C Naski; Q Wang; J Xu; D M Ornitz
Journal:  Nat Genet       Date:  1996-06       Impact factor: 38.330

9.  Identical mutations in three different fibroblast growth factor receptor genes in autosomal dominant craniosynostosis syndromes.

Authors:  G A Bellus; K Gaudenz; E H Zackai; L A Clarke; J Szabo; C A Francomano; M Muenke
Journal:  Nat Genet       Date:  1996-10       Impact factor: 38.330

10.  Missense FGFR3 mutations create cysteine residues in thanatophoric dwarfism type I (TD1).

Authors:  F Rousseau; V el Ghouzzi; A L Delezoide; L Legeai-Mallet; M Le Merrer; A Munnich; J Bonaventure
Journal:  Hum Mol Genet       Date:  1996-04       Impact factor: 6.150
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  117 in total

1.  Wdr5 is required for chick skeletal development.

Authors:  Shimei Zhu; Eric D Zhu; Sylvain Provot; Francesca Gori
Journal:  J Bone Miner Res       Date:  2010-11       Impact factor: 6.741

Review 2.  Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias.

Authors:  Silvie Foldynova-Trantirkova; William R Wilcox; Pavel Krejci
Journal:  Hum Mutat       Date:  2011-11-16       Impact factor: 4.878

3.  Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

Authors:  Xiuqin Zhang; Omar A Ibrahimi; Shaun K Olsen; Hisashi Umemori; Moosa Mohammadi; David M Ornitz
Journal:  J Biol Chem       Date:  2006-04-04       Impact factor: 5.157

4.  Wnt gene expression in the post-natal growth plate: regulation with chondrocyte differentiation.

Authors:  Anenisia C Andrade; Ola Nilsson; Kevin M Barnes; Jeffrey Baron
Journal:  Bone       Date:  2007-01-20       Impact factor: 4.398

5.  Roles of FGFR3 during morphogenesis of Meckel's cartilage and mandibular bones.

Authors:  Bruce A Havens; Dimitris Velonis; Mark S Kronenberg; Alex C Lichtler; Bonnie Oliver; Mina Mina
Journal:  Dev Biol       Date:  2008-02-13       Impact factor: 3.582

Review 6.  Signaling and transcriptional regulation in osteoblast commitment and differentiation.

Authors:  Wei Huang; Shuying Yang; Jianzhong Shao; Yi-Ping Li
Journal:  Front Biosci       Date:  2007-05-01

Review 7.  Molecular basis for skeletal variation: insights from developmental genetic studies in mice.

Authors:  C Kappen; A Neubüser; R Balling; R Finnell
Journal:  Birth Defects Res B Dev Reprod Toxicol       Date:  2007-12

8.  Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription.

Authors:  Weiguang Wang; Na Lian; Lingzhen Li; Heather E Moss; Weixi Wang; Daniel S Perrien; Florent Elefteriou; Xiangli Yang
Journal:  Development       Date:  2009-11-11       Impact factor: 6.868

9.  Involvement of fibroblast growth factor 18 in dedifferentiation of cultured human chondrocytes.

Authors:  H Yamaoka; S Nishizawa; Y Asawa; Y Fujihara; T Ogasawara; K Yamaoka; S Nagata; T Takato; K Hoshi
Journal:  Cell Prolif       Date:  2009-11-10       Impact factor: 6.831

10.  Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis.

Authors:  Nan Su; Qidi Sun; Can Li; Xiumin Lu; Huabing Qi; Siyu Chen; Jing Yang; Xiaolan Du; Ling Zhao; Qifen He; Min Jin; Yue Shen; Di Chen; Lin Chen
Journal:  Hum Mol Genet       Date:  2010-01-06       Impact factor: 6.150
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