Literature DB >> 18157899

Molecular basis for skeletal variation: insights from developmental genetic studies in mice.

C Kappen1, A Neubüser, R Balling, R Finnell.   

Abstract

Skeletal variations are common in humans, and potentially are caused by genetic as well as environmental factors. We here review molecular principles in skeletal development to develop a knowledge base of possible alterations that could explain variations in skeletal element number, shape or size. Environmental agents that induce variations, such as teratogens, likely interact with the molecular pathways that regulate skeletal development. (c) 2007 Wiley-Liss, Inc.

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Year:  2007        PMID： 18157899      PMCID： PMC3938168          DOI： 10.1002/bdrb.20136

Source DB:  PubMed          Journal:  Birth Defects Res B Dev Reprod Toxicol        ISSN： 1542-9733


  405 in total

Review 1.  Genetic regulation of somite formation.

Authors:  A Rawls; J Wilson-Rawls; E N Olson
Journal:  Curr Top Dev Biol       Date:  2000       Impact factor: 4.897

Review 2.  Genetics of osteoporosis.

Authors:  J A Eisman
Journal:  Endocr Rev       Date:  1999-12       Impact factor: 19.871

3.  Disruption of the homeobox gene Hoxb-6 in mice results in increased numbers of early erythrocyte progenitors.

Authors:  C Kappen
Journal:  Am J Hematol       Date:  2000-10       Impact factor: 10.047

Review 4.  Regulation of cartilage and bone differentiation by bone morphogenetic proteins.

Authors:  A H Reddi
Journal:  Curr Opin Cell Biol       Date:  1992-10       Impact factor: 8.382

Review 5.  The Wnt family of cell signalling molecules in postimplantation development of the mouse.

Authors:  A P McMahon; B J Gavin; B Parr; A Bradley; J A McMahon
Journal:  Ciba Found Symp       Date:  1992

6.  Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice.

Authors:  T Katagiri; S Boorla; J L Frendo; B L Hogan; G Karsenty
Journal:  Dev Genet       Date:  1998

Review 7.  The role of homeobox genes in limb development.

Authors:  B A Morgan; C J Tabin
Journal:  Curr Opin Genet Dev       Date:  1993-08       Impact factor: 5.578

8.  A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos.

Authors:  T Iwata; L Chen; C Li; D A Ovchinnikov; R R Behringer; C A Francomano; C X Deng
Journal:  Hum Mol Genet       Date:  2000-07-01       Impact factor: 6.150

Review 9.  The T genes in embryogenesis.

Authors:  B G Herrmann; A Kispert
Journal:  Trends Genet       Date:  1994-08       Impact factor: 11.639

10.  Two myogenic lineages within the developing somite.

Authors:  C P Ordahl; N M Le Douarin
Journal:  Development       Date:  1992-02       Impact factor: 6.868
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  3 in total

1.  Morpholino-mediated knockdown in primary chondrocytes implicates Hoxc8 in regulation of cell cycle progression.

Authors:  Suzan Kamel; Claudia Kruger; J Michael Salbaum; Claudia Kappen
Journal:  Bone       Date:  2008-11-21       Impact factor: 4.398

2.  Folate modulates Hox gene-controlled skeletal phenotypes.

Authors:  Claudia Kappen; Maria Alice Mello; Richard H Finnell; J Michael Salbaum
Journal:  Genesis       Date:  2004-07       Impact factor: 2.487

3.  Impact of the Endocannabinoid System on Bone Formation and Remodeling in p62 KO Mice.

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Journal:  Front Pharmacol       Date:  2022-03-22       Impact factor: 5.810
  3 in total

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