BACKGROUND: Oral-based antibiotic therapy is the standard of care in the management of cancer patients with low-risk neutropenic fever. Nevertheless, to the authors' knowledge, the best antibiotic regimen and the feasibility of ambulatory treatment have not been clearly defined. METHODS: The authors evaluated the efficacy and safety of moxifloxacin as outpatient treatment in cancer patients with febrile neutropenia who were selected according to the recently proposed Multinational Association for Supportive Care in Cancer (MASCC) risk assessment model. Moxifloxacin was given at a dose of 400 mg orally once daily. RESULTS: Fifty-four patients with solid and hematologic malignancies, the majority of whom (84%) had advanced disease, were included in the current study. The median neutrophil count at the time of study entry was 340/mm3 (range, 20-950/mm3) and the median duration of neutropenia was 4 days (range, 3-14 days). Of 55 neutropenic episodes, 50 (91%) had a successful outcome with a median time to defervescence of 2 days (range, 1-5 days). A multivariate analysis indicated that severe neutropenia (an absolute neutrophil count of < 100 mm3) was the only independent factor associated with treatment failure (P < 0.04). Moxifloxacin was found to be well tolerated and there were no infectious deaths reported. CONCLUSIONS: The results of the current study demonstrated that moxifloxacin was a highly effective and safe regimen in the outpatient treatment of cancer patients with febrile neutropenia. Copyright 2005 American Cancer Society.
BACKGROUND: Oral-based antibiotic therapy is the standard of care in the management of cancerpatients with low-risk neutropenic fever. Nevertheless, to the authors' knowledge, the best antibiotic regimen and the feasibility of ambulatory treatment have not been clearly defined. METHODS: The authors evaluated the efficacy and safety of moxifloxacin as outpatient treatment in cancerpatients with febrile neutropenia who were selected according to the recently proposed Multinational Association for Supportive Care in Cancer (MASCC) risk assessment model. Moxifloxacin was given at a dose of 400 mg orally once daily. RESULTS: Fifty-four patients with solid and hematologic malignancies, the majority of whom (84%) had advanced disease, were included in the current study. The median neutrophil count at the time of study entry was 340/mm3 (range, 20-950/mm3) and the median duration of neutropenia was 4 days (range, 3-14 days). Of 55 neutropenic episodes, 50 (91%) had a successful outcome with a median time to defervescence of 2 days (range, 1-5 days). A multivariate analysis indicated that severe neutropenia (an absolute neutrophil count of < 100 mm3) was the only independent factor associated with treatment failure (P < 0.04). Moxifloxacin was found to be well tolerated and there were no infectious deaths reported. CONCLUSIONS: The results of the current study demonstrated that moxifloxacin was a highly effective and safe regimen in the outpatient treatment of cancerpatients with febrile neutropenia. Copyright 2005 American Cancer Society.
Authors: Young Eun Ha; Jae-Hoon Song; Won Ki Kang; Kyong Ran Peck; Doo Ryeon Chung; Cheol-In Kang; Mi-Kyong Joung; Eun-Jeong Joo; Kyung Mok Shon Journal: Support Care Cancer Date: 2010-10-08 Impact factor: 3.603
Authors: Kenneth V I Rolston; Susan E Frisbee-Hume; Shreyaskumar Patel; Ellen F Manzullo; Robert S Benjamin Journal: Support Care Cancer Date: 2009-04-22 Impact factor: 3.603
Authors: Luciano de Souza Viana; José Carlos Serufo; Manoel Otávio da Costa Rocha; Renato Nogueira Costa; Roberto Carlos Duarte Journal: Support Care Cancer Date: 2007-10-25 Impact factor: 3.603
Authors: Catherine Sebban; Sophie Dussart; Christine Fuhrmann; Hervé Ghesquieres; Isabelle Rodrigues; Lionel Geoffrois; Yves Devaux; Laurence Lancry; Giselle Chvetzoff; Thomas Bachelot; Maria Chelghoum; Pierre Biron Journal: Support Care Cancer Date: 2008-01-15 Impact factor: 3.603