| Literature DB >> 15854907 |
Erica Davis1, Florian Caiment, Xavier Tordoir, Jérôme Cavaillé, Anne Ferguson-Smith, Noelle Cockett, Michel Georges, Carole Charlier.
Abstract
The Dlk1-Gtl2 imprinted domain, encompassing the callipyge (CLPG) locus in sheep, has recently been shown to harbor a large number of maternally expressed miRNA genes [1, 2]. Two of these (mir127 and mir136) are processed from a transcript (antiPeg11) that is antisense to Rtl1/Peg11, a paternally expressed intronless gene with homology to the gag and pol polyproteins of Sushi-like retroelements [3]. We herein demonstrate that several additional miRNAs are processed from antiPeg11 and that these regulate Rtl1/Peg11 in trans by guiding RISC-mediated cleavage of its mRNA. This is the first demonstration of miRNA-mediated RNAi involving imprinted genes in mammals.Entities:
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Year: 2005 PMID： 15854907 DOI： 10.1016/j.cub.2005.02.060
Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834