| Literature DB >> 15848300 |
Antonella Tinari1, Agostina Pietrantoni, Maria Grazia Ammendolia, Piera Valenti, Fabiana Superti.
Abstract
Lactoferrin is a glycoprotein and plays an important role in defence against pathogens. Although the antiviral activity of lactoferrin is one of the major biological functions of such protein, the mechanism of action is still under debate. The effect of lactoferrin on echovirus 6 infection in vitro was analysed and results showed that (i) cells infected with echovirus 6, died as a result of apoptosis and that (ii) programmed cell death was inhibited by lactoferrin treatment. In this report, we demonstrate that lactoferrin can exert its anti-enteroviral activity by preventing viral-induced apoptosis.Entities:
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Year: 2005 PMID： 15848300 DOI： 10.1016/j.ijantimicag.2005.02.011
Source DB: PubMed Journal: Int J Antimicrob Agents ISSN： 0924-8579 Impact factor: 5.283