| Literature DB >> 15844963 |
Marcelino Gutiérrez1, Todd L Capson, Héctor M Guzmán, José González, Eduardo Ortega-Barría, Emilio Quiñoá, Ricardo Riguera.
Abstract
Six furanocembranolides (1-6) and one pseudopterolide (7) have been isolated from the octocorals Leptogorgia alba and Leptogorgia rigida, collected on the Pacific coast of Panama. Compound 1, named leptolide, has a new structure closely related to the neurotoxin lophotoxin (3). The X-ray structures of 1-3 were determined, and the absolute configurations of 2-7 are discussed. Compounds 1-7 were evaluated in vitro against drug-resistant Plasmodium falciparum.Entities:
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Year: 2005 PMID： 15844963 DOI： 10.1021/np049745z
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050