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Literature DB >> 15844952

The psammaplysenes, specific inhibitors of FOXO1a nuclear export.

Frank C Schroeder¹, Tweeny R Kau, Pamela A Silver, Jon Clardy.

Abstract

A small collection of marine natural product extracts was screened for compounds that would compensate lost tumor suppressor functionality in PTEN-deficient cells. From the most active extract, the previously unreported bromotyrosine derivative, psammaplysene A (1), was identified. Psammaplysene A compensates for PTEN loss by relocalizing the transcription factor FOXO1a to the nucleus.

Entities: Chemical Disease Gene

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Year: 2005 PMID： 15844952 DOI： 10.1021/np049624z

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

21 in total

1. Preparation of a psammaplysene-based library.

Authors: Savvas N Georgiades; Jon Clardy
Journal: Org Lett Date: 2006-09-14 Impact factor: 6.005

2. Induction of apoptosis in endometrial cancer cells by psammaplysene A involves FOXO1.

Authors: Emily Berry; Jennifer L Hardt; Jon Clardy; John R Lurain; J Julie Kim
Journal: Gynecol Oncol Date: 2008-11-28 Impact factor: 5.482

3. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases.

Authors: Jelena Mojsilovic-Petrovic; Natalia Nedelsky; Marco Boccitto; Itzhak Mano; Savvas N Georgiades; Weiguo Zhou; Yuhong Liu; Rachael L Neve; J Paul Taylor; Monica Driscoll; Jon Clardy; Diane Merry; Robert G Kalb
Journal: J Neurosci Date: 2009-06-24 Impact factor: 6.167

4. Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension.

Authors: Rajkumar Savai; Hamza M Al-Tamari; Daniel Sedding; Baktybek Kojonazarov; Christian Muecke; Rebecca Teske; Mario R Capecchi; Norbert Weissmann; Friedrich Grimminger; Werner Seeger; Ralph Theo Schermuly; Soni Savai Pullamsetti
Journal: Nat Med Date: 2014-10-26 Impact factor: 53.440

The psammaplysenes, specific inhibitors of FOXO1a nuclear export.

1. Preparation of a psammaplysene-based library.

2. Induction of apoptosis in endometrial cancer cells by psammaplysene A involves FOXO1.

3. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases.

4. Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension.

Review 5. Deciphering the role of forkhead transcription factors in cancer therapy.

6. FOXO1: a potential target for human diseases.

Review 7. Dysregulation of apoptotic signaling in cancer: molecular mechanisms and therapeutic opportunities.

8. FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells.

Review 9. A new fork for clinical application: targeting forkhead transcription factors in cancer.

Review 10. Marine pharmacology in 2005-2006: antitumour and cytotoxic compounds.