Literature DB >> 1584454

Histamine H1 receptors in human brain visualized in vivo by [11C]doxepin and positron emission tomography.

K Yanai1, T Watanabe, H Yokoyama, K Meguro, J Hatazawa, M Itoh, R Iwata, K Ishiwata, T Takahashi, T Ido.   

Abstract

Histamine H1 receptors in the living human brain were visualized by positron emission tomography (PET) using [N-11C-methyl]-(E)-doxepin ([11C]doxepin). The regional distribution of the carbon-11-labeled compound in the brain corresponded well with that of the histamine H1 receptors measured in vitro using [3H]pyrilamine. The radioactivity in the brain was significantly reduced by intravenous pretreatment with d-chlorpheniramine (5 mg), a histamine H1 antagonist. The regional distribution of [11C]doxepin in the brain 45-90 min after its injection was almost the same as that of [11C]pyrilamine in the brain. These results indicate that [11C]doxepin is useful for measuring histamine H1 receptors in human brain by PET.

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Year:  1992        PMID： 1584454     DOI： 10.1016/0304-3940(92)90390-s

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  10 in total

1.  Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine.

Authors:  M Tagawa; M Kano; N Okamura; M Higuchi; M Matsuda; Y Mizuki; H Arai; R Iwata; T Fujii; S Komemushi; T Ido; M Itoh; H Sasaki; T Watanabe; K Yanai
Journal:  Br J Clin Pharmacol       Date:  2001-11       Impact factor: 4.335

2.  Histamine and Seizures : Implications for the Treatment of Epilepsy.

Authors:  H Yokoyama; K Iinuma
Journal:  CNS Drugs       Date:  1996-05       Impact factor: 5.749

3.  Fully automated production of 11C-doxepin for PET imaging histamine H1 receptor.

Authors:  Hancheng Cai; Thomas J Mangner; Otto Muzik; Xin Lu; Pulak K Chakraborty; Diane C Chugani; Harry T Chugani
Journal:  Mol Imaging Biol       Date:  2012-10       Impact factor: 3.488

4.  Functional neuroimaging of cognition impaired by a classical antihistamine, d-chlorpheniramine.

Authors:  N Okamura; K Yanai; M Higuchi; J Sakai; R Iwata; T Ido; H Sasaki; T Watanabe; M Itoh
Journal:  Br J Pharmacol       Date:  2000-01       Impact factor: 8.739

5.  Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors.

Authors:  I Inoue; K Yanai; D Kitamura; I Taniuchi; T Kobayashi; K Niimura; T Watanabe; T Watanabe
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-12       Impact factor: 11.205

Review 6.  International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.

Authors:  Pertti Panula; Paul L Chazot; Marlon Cowart; Ralf Gutzmer; Rob Leurs; Wai L S Liu; Holger Stark; Robin L Thurmond; Helmut L Haas
Journal:  Pharmacol Rev       Date:  2015-07       Impact factor: 25.468

Review 7.  Histamine Neuroimaging in Stress-Related Disorders.

Authors:  Shin Fukudo; Michiko Kano; Yasuhiro Sato; Tomohiko Muratsubaki; Motoyori Kanazawa; Manabu Tashiro; Kazuhiko Yanai
Journal:  Curr Top Behav Neurosci       Date:  2022

8.  Chemical Probes for Histamine Receptor Subtypes.

Authors:  Markus Falkenstein; Milica Elek; Holger Stark
Journal:  Curr Top Behav Neurosci       Date:  2022

9.  Antihistamine induced blood oxygenation level dependent response changes related to visual processes during sensori-motor performance.

Authors:  Peter van Ruitenbeek; Annemiek Vermeeren; Mitul Ashok Mehta; Eva Isabell Drexler; Willem Jan Riedel
Journal:  Hum Brain Mapp       Date:  2013-10-18       Impact factor: 5.038

10.  The Use of Sleep Medication in Youth Residential Care.

Authors:  Beate Oerbeck; Kristin Romvig Overgaard; Vidar Hjellvik; Jørgen G Bramness; Berit Hjelde Hansen; Lars Lien
Journal:  J Child Adolesc Psychopharmacol       Date:  2020-01-23       Impact factor: 2.576
  10 in total

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