Literature DB >> 15844511

Proteomic LC-MS systems using nanoscale liquid chromatography with tandem mass spectrometry.

Yasushi Ishihama1.   

Abstract

Current nano-scale liquid chromatography-tandem mass spectrometry (nanoLC-MS/MS) approaches in proteome research are reviewed from an analytical perspective. For comprehensive analysis of cellular proteins, analytical methods with higher resolution, sensitivity, and wider dynamic range are required. Miniaturized LC coupled with tandem mass spectrometry is currently one of the most versatile techniques. In this review, the current status of nanoLC-MS/MS systems as well as data management systems is addressed. In addition, the future prospects for complete proteomics are discussed.

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Year:  2005        PMID： 15844511     DOI： 10.1016/j.chroma.2004.10.107

Source DB:  PubMed          Journal:  J Chromatogr A        ISSN： 0021-9673            Impact factor:   4.759


  24 in total

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