OBJECTIVE: We compared the effectiveness of a new continuous positive airway pressure (CPAP) device (neonatal helmet CPAP) with a conventional nasal CPAP system in preterm neonates needing continuous distending pressure. DESIGN AND SETTING: Randomized, physiological, cross-over study in a tertiary referral, neonatal intensive care unit in a university teaching hospital. PATIENTS: Twenty very low birth weight infants with a postnatal age greater than 24 h who were receiving nasal CPAP for apnea and/or mild respiratory distress were enrolled. INTERVENTIONS:CPAP delivered by neonatal helmet CPAP and nasal CPAP in random order for two subsequent 90-min periods. MEASUREMENTS AND RESULTS: Were continuously measured the Neonatal Infant Pain Scale (NIPS) score, oxygen requirements, respiratory rate, heart rate, oxygen saturation, transcutaneous PO(2) (tcPO(2)) and PCO(2) (tcPCO(2)), blood pressure, and desaturations. NIPS scores were significantly lower when the infants were on the neonatal helmet CPAP than when they were on nasal CPAP (0.26+/-0.07 vs. 0.63+/-0.12). The other studied parameters did not differ between the two CPAP modes. The number of desaturations was reduced during the neonatal helmet CPAP treatment (18 vs. 32), although this difference was not significant. CONCLUSIONS: In this short-term physiological study the neonatal helmet CPAP appears to be as good as the golden standard for managing preterm infants needing continuous distending pressure, with enhanced tolerability. Further evaluation in a randomized clinical trial is needed to confirm these findings.
RCT Entities:
OBJECTIVE: We compared the effectiveness of a new continuous positive airway pressure (CPAP) device (neonatal helmet CPAP) with a conventional nasal CPAP system in preterm neonates needing continuous distending pressure. DESIGN AND SETTING: Randomized, physiological, cross-over study in a tertiary referral, neonatal intensive care unit in a university teaching hospital. PATIENTS: Twenty very low birth weight infants with a postnatal age greater than 24 h who were receiving nasal CPAP for apnea and/or mild respiratory distress were enrolled. INTERVENTIONS: CPAP delivered by neonatal helmet CPAP and nasal CPAP in random order for two subsequent 90-min periods. MEASUREMENTS AND RESULTS: Were continuously measured the Neonatal InfantPain Scale (NIPS) score, oxygen requirements, respiratory rate, heart rate, oxygen saturation, transcutaneous PO(2) (tcPO(2)) and PCO(2) (tcPCO(2)), blood pressure, and desaturations. NIPS scores were significantly lower when the infants were on the neonatal helmet CPAP than when they were on nasal CPAP (0.26+/-0.07 vs. 0.63+/-0.12). The other studied parameters did not differ between the two CPAP modes. The number of desaturations was reduced during the neonatal helmet CPAP treatment (18 vs. 32), although this difference was not significant. CONCLUSIONS: In this short-term physiological study the neonatal helmet CPAP appears to be as good as the golden standard for managing preterm infants needing continuous distending pressure, with enhanced tolerability. Further evaluation in a randomized clinical trial is needed to confirm these findings.
Authors: M E Avery; W H Tooley; J B Keller; S S Hurd; M H Bryan; R B Cotton; M F Epstein; P M Fitzhardinge; C B Hansen; T N Hansen Journal: Pediatrics Date: 1987-01 Impact factor: 7.124
Authors: Nicolò Patroniti; Giuseppe Foti; Annamaria Manfio; Anna Coppo; Giacomo Bellani; Antonio Pesenti Journal: Intensive Care Med Date: 2003-08-28 Impact factor: 17.440
Authors: Peter Andrews; Elie Azoulay; Massimo Antonelli; Laurent Brochard; Christian Brun-Buisson; Geoffrey Dobb; Jean-Yves Fagon; Herwig Gerlach; Johan Groeneveld; Jordi Mancebo; Philipp Metnitz; Stefano Nava; Jerome Pugin; Michael Pinsky; Peter Radermacher; Christian Richard; Robert Tasker Journal: Intensive Care Med Date: 2006-02-18 Impact factor: 17.440