| Literature DB >> 15837624 |
Deepa B Shankar1, Jerry C Cheng, Kentaro Kinjo, Noah Federman, Theodore B Moore, Amandip Gill, Nagesh P Rao, Elliot M Landaw, Kathleen M Sakamoto.
Abstract
CREB is a transcription factor that functions in glucose homeostasis, growth factor-dependent cell survival, and memory. In this study, we describe a role of CREB in human cancer. CREB overexpression is associated with increased risk of relapse and decreased event-free survival. CREB levels are elevated in blast cells from patients with acute myeloid leukemia. To understand the role of CREB in leukemogenesis, we studied the biological consequences of CREB overexpression in primary human leukemia cells, leukemia cell lines, and transgenic mice. Our results demonstrate that CREB promotes abnormal proliferation and survival of myeloid cells in vitro and in vivo through upregulation of specific target genes. Thus, we report that CREB is implicated in myeloid cell transformation.Entities:
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Year: 2005 PMID： 15837624 DOI： 10.1016/j.ccr.2005.02.018
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743