Literature DB >> 15837333

The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production.

Steven K Laughlin1, Michael P Clark, Jane F Djung, Adam Golebiowski, Todd A Brugel, Mark Sabat, Roger G Bookland, Matthew J Laufersweiler, John C VanRens, Jennifer A Townes, Biswanath De, Lily C Hsieh, Susan C Xu, Richard L Walter, Marlene J Mekel, Michael J Janusz.   

Abstract

4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-alpha) inhibitors, which contain a novel isoxazolone five-membered heterocyclic core are described. Many showed sub-micromolar activity against lipopolysaccharide-induced TNF-alpha production.

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Year:  2005        PMID： 15837333     DOI： 10.1016/j.bmcl.2005.02.066

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Crystal structure and Hirshfeld surface analysis of (Z)-3-methyl-4-(thio-phen-2-yl-methyl-idene)isoxazol-5(4H)-one.

Authors:  Rima Laroum; Assia Benouatas; Noudjoud Hamdouni; Wissame Zemamouche; Ali Boudjada; Abdelmadjid Debache
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2021-03-12

2.  4-(4-Fluoro-phen-yl)-2-methyl-3-(1-oxy-4-pyridyl)isoxazol-5(2H)-one.

Authors:  Simona Margutti; Dieter Schollmeyer; Stefan Laufer
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-01-23

3.  4-[4-(4-Fluoro-phen-yl)-2-methyl-5-oxo-2,5-dihydro-isoxazol-3-yl]-1-methyl-pyridinium iodide-4-[3-(4-fluoro-phen-yl)-2-methyl-5-oxo-2,5-dihydro-isoxazol-4-yl]-1-methyl-pyridinium iodide (0.6/0.4).

Authors:  Simona Margutti; Dieter Schollmeyer; Stefan Laufer
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-18

4.  Identification of potential TNF-α inhibitors: from in silico to in vitro studies.

Authors:  Komal Zia; Sajda Ashraf; Almas Jabeen; Maria Saeed; Mohammad Nur-E-Alam; Sarfaraz Ahmed; Adnan J Al-Rehaily; Zaheer Ul-Haq
Journal:  Sci Rep       Date:  2020-12-01       Impact factor: 4.379

5.  Magnetic sulfonated polysaccharides as efficient catalysts for synthesis of isoxazole-5-one derivatives possessing a substituted pyrrole ring, as anti-cancer agents.

Authors:  Zarrin Ghasemi; Afsaneh Hamidian Amale; Sajjad Azizi; Sepideh Valizadeh; Jafar Soleymani
Journal:  RSC Adv       Date:  2021-11-17       Impact factor: 3.361
  5 in total

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