| Literature DB >> 15837314 |
Richard L Jarvest1, Symon G Erskine, Andrew K Forrest, Andrew P Fosberry, Martin J Hibbs, Joanna J Jones, Peter J O'Hanlon, Robert J Sheppard, Angela Worby.
Abstract
High throughput screening of Staphylococcus aureus phenylalanyl tRNA synthetase (FRS) identified ethanolamine 1 as a sub-micromolar hit. Optimisation studies led to the enantiospecific lead 64, a single-figure nanomolar inhibitor. The inhibitor series shows selectivity with respect to the mammalian enzyme and the potential for broad spectrum bacterial FRS inhibition.Entities:
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Year: 2005 PMID： 15837314 DOI： 10.1016/j.bmcl.2005.03.003
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823