| Literature DB >> 15837311 |
Paola Barraja1, Laura Sciabica, Patrizia Diana, Antonino Lauria, Alessandra Montalbano, Anna Maria Almerico, Gaetano Dattolo, Girolamo Cirrincione, Silvia Disarò, Giuseppe Basso, Giampietro Viola, Francesco Dall'Acqua.
Abstract
A series of derivatives of the new ring system thiopyrano[2,3-e]indol-2-one was prepared with the aim of obtaining new photochemotherapeutic drugs. Biological screenings were performed on this new class of photoactivable drugs and a strong antiproliferative effect was observed upon irradiation with UVA light. The compound bearing a methyl substituent at the pyrrole nitrogen resulted as the most interesting showing IC50 in the nanomolar range.Entities:
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Year: 2005 PMID： 15837311 DOI： 10.1016/j.bmcl.2005.03.016
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823