Riccardo Asero1. 1. Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italia. r.asero@libero.it
Abstract
BACKGROUND: There is some evidence that specific immunotherapy may induce de novo sensitization to proteins contained in the allergen extract. This raises the possibility that the novel sensitization to cross-reacting allergens may cause food allergies. OBJECTIVE: The aim of this study was to assess whether injection of mite-specific immunotherapy (SIT) may induce sensitization to shrimp tropomyosin. METHODS: Seventy mite-allergic subjects who did not show any shrimp sensitization at baseline were followed up for at least 3 years. Thirty-one of them underwent a 3-year SIT course, 39 served as controls. At the follow-up visit, SPTs with both fresh shrimp and commercial extract were performed, and patients underwent an open oral challenge with shrimp. RESULTS: Neither patient nor control had become sensitized to shrimp allergens at the end of the study period. Both patients and controls reported the regular intake of crustaceans and/or molluscs. CONCLUSION: Injection SIT with house dust mite extracts does not seem to induce de novo tropomyosin sensitization in mite-allergic patients. Copyright 2005 S. Karger AG, Basel
BACKGROUND: There is some evidence that specific immunotherapy may induce de novo sensitization to proteins contained in the allergen extract. This raises the possibility that the novel sensitization to cross-reacting allergens may cause food allergies. OBJECTIVE: The aim of this study was to assess whether injection of mite-specific immunotherapy (SIT) may induce sensitization to shrimp tropomyosin. METHODS: Seventy mite-allergic subjects who did not show any shrimp sensitization at baseline were followed up for at least 3 years. Thirty-one of them underwent a 3-year SIT course, 39 served as controls. At the follow-up visit, SPTs with both fresh shrimp and commercial extract were performed, and patients underwent an open oral challenge with shrimp. RESULTS: Neither patient nor control had become sensitized to shrimp allergens at the end of the study period. Both patients and controls reported the regular intake of crustaceans and/or molluscs. CONCLUSION: Injection SIT with house dust mite extracts does not seem to induce de novo tropomyosin sensitization in mite-allergicpatients. Copyright 2005 S. Karger AG, Basel
Authors: Renato E Rossi; Giorgio Monasterolo; Cristoforo Incorvaia; Philippe Moingeon; Franco Frati; Giovanni Passalacqua; Lucilla Rossi; Giorgio W Canonica Journal: Clin Mol Allergy Date: 2010-03-15
Authors: Lana Rosenfield; Michael William Tsoulis; Kirolos Milio; Meghan Schnittke; Harold Kim Journal: Allergy Asthma Clin Immunol Date: 2017-01-19 Impact factor: 3.406