| Literature DB >> 15830842 |
Y Sakagami1, M Iinuma, K G N P Piyasena, H R W Dharmaratne.
Abstract
alpha-Mangostin, isolated from the stem bark of Garcinia mangostana L., was found to be active against vancomycin resistant Enterococci (VRE) and methicillin resistant Staphylococcus aureus (MRSA), with MIC values of 6.25 and 6.25 to 12.5 microg/ml, respectively. Our studies showed synergism between alpha-mangostin and gentamicin (GM) against VRE, and alpha-mangostin and vancomycin hydrochloride (VCM) against MRSA. Further studies showed partial synergism between alpha-mangostin and commercially available antibiotics such as ampicillin and minocycline. These findings suggested that alpha-mangostin alone or in combination with GM against VRE and in combination with VCM against MRSA might be useful in controlling VRE and MRSA infections.Entities:
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Year: 2005 PMID： 15830842 DOI： 10.1016/j.phymed.2003.09.012
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340