Literature DB >> 15830479

Comparison of enzymatic and microbiological gentamicin assays.

A L Smith, J A Waitz, D H Smith, E M Oden, B B Emerson.   

Abstract

The correlation coefficient between the rapid enzymatic and the overnight microbiological assays for 211 urine and serum specimens was 0.96. The 95% confidence limits yielded a correlation coefficient between 0.92 and 0.98. Both methods tended to underestimate the amount of a gentamicin added to urine. When only serum samples were considered, the predicted value obtained from the linear regression analysis of either method was within 0.57 mug/ml 99% of the time. This high degree of positive correlation will permit safe rapid adjustment of individualized patient gentamicin dosages.

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Year:  1974        PMID: 15830479      PMCID: PMC444643          DOI: 10.1128/AAC.6.3.316

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  8 in total

1.  A rapid chemical assay for gentamicin.

Authors:  D H Smith; B Van Otto; A L Smith
Journal:  N Engl J Med       Date:  1972-03-16       Impact factor: 91.245

2.  Simple, rapid method for assay of aminoglycoside antibiotics.

Authors:  P Noone; J R Pattison; D Samson
Journal:  Lancet       Date:  1971-07-03       Impact factor: 79.321

3.  Radioimmunoassay of an antibiotic: gentamicin.

Authors:  J E Lewis; J C Nelson; H A Elder
Journal:  Nat New Biol       Date:  1972-10-18

4.  Four-hour microbiological assay of gentamicin in serum.

Authors:  E Warren; R J Snyder; I I Washington JA
Journal:  Antimicrob Agents Chemother       Date:  1972-01       Impact factor: 5.191

5.  Rapid microassay of gentamicin, kanamycin, neomycin, streptomycin, and vancomycin in serum or plasma.

Authors:  L D Sabath; J I Casey; P A Ruch; L L Stumpf; M Finland
Journal:  J Lab Clin Med       Date:  1971-09

6.  Gentamicin dosages for renal insufficiency. Adjustments based on endogenous creatinine clearance and serum creatinine concentration.

Authors:  M C McHenry; T L Gavan; R W Gifford; N A Geurkink; R A Van Ommen; M A Town; J G Wagner
Journal:  Ann Intern Med       Date:  1971-02       Impact factor: 25.391

7.  Gentamicin:adenine mononucleotide transferase: partial purification, characterization, and use in the clinical quantitation of gentamicin.

Authors:  A L Smith; D H Smith
Journal:  J Infect Dis       Date:  1974-04       Impact factor: 5.226

8.  Radioimmunoassay for measurement of gentamicin in blood.

Authors:  W A Mahon; J Ezer; T W Wilson
Journal:  Antimicrob Agents Chemother       Date:  1973-05       Impact factor: 5.191

  8 in total
  6 in total

1.  Properties of the gentamicin acetyltransferase enzyme and application to the assay of aminoglycoside antibiotics.

Authors:  J M Broughall; D S Reeves
Journal:  Antimicrob Agents Chemother       Date:  1975-08       Impact factor: 5.191

2.  Pharmacokinetics of gentamicin in malnourished infants.

Authors:  M E Bravo; A Arancibia; S Jarpa; P M Carpentier; A N Jahn
Journal:  Eur J Clin Pharmacol       Date:  1982       Impact factor: 2.953

3.  Comparative analysis of two rapid, automated methods for determining aminoglycoside levels.

Authors:  J H Ngui-Yen; P W Doyle; J A Smith
Journal:  J Clin Microbiol       Date:  1984-11       Impact factor: 5.948

4.  Comparative evaluation of three methods for measuring gentamicin and tobramycin in serum.

Authors:  J H Ngui-Yen; T Hofmann; M Wigmore; J A Smith
Journal:  Antimicrob Agents Chemother       Date:  1981-12       Impact factor: 5.191

5.  Spectrophotometric assay for amikacin using purified kanamycin acetyltransferase.

Authors:  E Scarbrough; J W Williams; D B Northrop
Journal:  Antimicrob Agents Chemother       Date:  1979-08       Impact factor: 5.191

Review 6.  Why monitor serum levels of gentamicin?

Authors:  M Barza; M Lauermann
Journal:  Clin Pharmacokinet       Date:  1978 May-Jun       Impact factor: 6.447

  6 in total

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