Literature DB >> 15829988

PDE-5 inhibitor, Vardenafil, increases circulating progenitor cells in humans.

C Foresta1, A Lana, A Cabrelle, M Ferigo, N Caretta, A Garolla, G Palù, A Ferlin.   

Abstract

Bone marrow-derived endothelial progenitor cells (EPCs) originate from haematopoietic stem cells in bone marrow and migrate into the peripheral circulation to promote endothelial repair and neovascularization. The number of circulating progenitor cells is reduced in patients with cardiovascular risk factor. The aim of our study was to determine the number of these cells in healthy patients and to evaluate the effect of Vardenfil, a phosphodiesterases-5 (PDE-5) inhibitor, in the number of circulating EPCs. In our study, we found a significant increase in the number of these cells after the drug administration.

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Year:  2005        PMID： 15829988     DOI： 10.1038/sj.ijir.3901325

Source DB:  PubMed          Journal:  Int J Impot Res        ISSN： 0955-9930            Impact factor:   2.896


  10 in total

Review 1.  Nitric oxide-cyclic GMP signaling in stem cell differentiation.

Authors:  Kalpana Mujoo; Joshua S Krumenacker; Ferid Murad
Journal:  Free Radic Biol Med       Date:  2011-10-06       Impact factor: 7.376

2.  Penile rehabilitation after radical prostatectomy: important therapy or wishful thinking?

Authors:  Joseph E Dall'era; Jesse N Mills; Hari K Koul; Randall B Meacham
Journal:  Rev Urol       Date:  2006

Review 3.  Treating erectile dysfunction by endothelial rehabilitation with phosphodiesterase 5 inhibitors.

Authors:  Frank Sommer; Wolfgang Schulze
Journal:  World J Urol       Date:  2005-11-05       Impact factor: 4.226

4.  Phosphodiesterase inhibition with tadalafil provides longer and sustained protection of stem cells.

Authors:  Husnain Kh Haider; Yun-Jung Lee; Shujia Jiang; Rafeeq P H Ahmed; Mok Ryon; Muhammad Ashraf
Journal:  Am J Physiol Heart Circ Physiol       Date:  2010-09-10       Impact factor: 4.733

Review 5.  Dynamics of progenitor cells and ventricular assist device intervention.

Authors:  Anastasia Tsiavou; Athanassios Manginas
Journal:  J Cardiovasc Transl Res       Date:  2009-10-22       Impact factor: 4.132

6.  Tadalafil, a Phosphodiesterase Inhibitor Protects Stem Cells over Longer Period Against Hypoxia/Reoxygenation Injury Through STAT3/PKG-I Signaling.

Authors:  Sanjay Kumar; Muhammad Ashraf
Journal:  Stem Cells Dev       Date:  2015-02-25       Impact factor: 3.272

Review 7.  Endothelial Progenitor Cells as Biomarkers of Cardiovascular Pathologies: A Narrative Review.

Authors:  Paul Philipp Heinisch; Corina Bello; Maximilian Y Emmert; Thierry Carrel; Martina Dreßen; Jürgen Hörer; Bernhard Winkler; Markus M Luedi
Journal:  Cells       Date:  2022-05-18       Impact factor: 7.666

8.  Chronic treatment with a PDE5 inhibitor increases contractile force of normal bladder in rats.

Authors:  Seiji Matsumoto; Tadashi Hanai; Hirotsugu Uemura
Journal:  Int Urol Nephrol       Date:  2009-05-16       Impact factor: 2.370

Review 9.  Erectile Dysfunction Treatment Using Stem Cells: A Review.

Authors:  Vassilis Protogerou; Dimosthenis Chrysikos; Vasileios Karampelias; Ypatios Spanidis; El Bisari Sara; Theodoros Troupis
Journal:  Medicines (Basel)       Date:  2021-01-06

Review 10.  Intracavernous administration of bone marrow mononuclear cells: a new method of treating erectile dysfunction?

Authors:  Thomas E Ichim; Timothy Warbington; Octav Cristea; Joseph L Chin; Amit N Patel
Journal:  J Transl Med       Date:  2013-06-09       Impact factor: 5.531
  10 in total

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