OBJECTIVE: In the current study, the potential DNA damage associated with exposure to a number of antimicrobial endodontic compounds was assessed by the single cell gel (comet) assay in vitro. STUDY DESIGN: Chinese hamster ovary (CHO) cells were exposed to formocresol, paramonochlorophenol, calcium hydroxide, or chlorhexidine at final concentration ranging from 0.01% to 1%. RESULTS: Formocresol, paramonochlorophenol, and calcium hydroxide, as well as chlorhexidine in all concentrations tested did not contribute to the DNA damage. CONCLUSION: These findings are clinically relevant since they represent an important contribution to the correct evaluation of the potential health risk associated with exposure to dental agents.
OBJECTIVE: In the current study, the potential DNA damage associated with exposure to a number of antimicrobial endodontic compounds was assessed by the single cell gel (comet) assay in vitro. STUDY DESIGN: Chinese hamster ovary (CHO) cells were exposed to formocresol, paramonochlorophenol, calcium hydroxide, or chlorhexidine at final concentration ranging from 0.01% to 1%. RESULTS:Formocresol, paramonochlorophenol, and calcium hydroxide, as well as chlorhexidine in all concentrations tested did not contribute to the DNA damage. CONCLUSION: These findings are clinically relevant since they represent an important contribution to the correct evaluation of the potential health risk associated with exposure to dental agents.
Authors: Daniel Araki Ribeiro; Mariangela Esther Alencar Marques; Daisy Maria Favero Salvadori Journal: J Mater Sci Mater Med Date: 2006-06 Impact factor: 3.896
Authors: Mariana Gobbo Braz; Joao Paulo de Castro Marcondes; Mariza Akemi Matsumoto; Marco Antonio Hungaro Duarte; Daisy Maria Favero Salvadori; Daniel Araki Ribeiro Journal: J Mater Sci Mater Med Date: 2007-07-10 Impact factor: 3.896