| Literature DB >> 15828843 |
Michael C Pirrung1, Sunil V Pansare, Koushik Das Sarma, Kathy A Keith, Earl R Kern.
Abstract
Novel strategies are required to combat pox virus infections, whether caused by escape of viruses such as monkeypox from indigenous areas or intentional release of smallpox. Anti-smallpox drugs with a unique mode of antiviral action, inhibition of transcription termination, were known but not therapeutically useful. Using a combinatorial method, variants of the basic isatin-beta-thiosemicarbazone structure were prepared and examined for cytotoxicity and antiviral activity in vaccinia virus- and cowpox virus-infected human cells. Potent and much more selective N-aminomethyl-isatin-beta-thiosemicarbazones were discovered.Entities:
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Year: 2005 PMID： 15828843 DOI： 10.1021/jm049147h
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446