BACKGROUND: Carcinoma of the gingivobuccal complex is commonly associated with the use of smokeless tobacco known as "quid." METHODS: We conducted a retrospective chart review of 511 patients with advanced cancer of gingivobuccal complex surgically treated during 1994 to 1995. We evaluated patterns of disease failure in these patients and correlated disease-free survival with various prognostic factors. RESULTS: During a median follow-up of 46 months, 159 locoregional recurrences and 11 distant metastases were detected in 148 patients. Seventy-nine percent of the recurrences appeared within 18 months of surgery, and the median survival for patients with recurrent disease was less than 4 months. Two-year and 5-year disease-free survival rates were 64% and 57%, respectively. On multivariate analysis, disease-free survival showed significant correlation with skin involvement and extracapsular spread. CONCLUSIONS: Gingivobuccal cancers usually fail locoregionally. Soft tissue infiltration and extracapsular spread of nodal disease influence disease-free survival.
BACKGROUND:Carcinoma of the gingivobuccal complex is commonly associated with the use of smokeless tobacco known as "quid." METHODS: We conducted a retrospective chart review of 511 patients with advanced cancer of gingivobuccal complex surgically treated during 1994 to 1995. We evaluated patterns of disease failure in these patients and correlated disease-free survival with various prognostic factors. RESULTS: During a median follow-up of 46 months, 159 locoregional recurrences and 11 distant metastases were detected in 148 patients. Seventy-nine percent of the recurrences appeared within 18 months of surgery, and the median survival for patients with recurrent disease was less than 4 months. Two-year and 5-year disease-free survival rates were 64% and 57%, respectively. On multivariate analysis, disease-free survival showed significant correlation with skin involvement and extracapsular spread. CONCLUSIONS:Gingivobuccal cancers usually fail locoregionally. Soft tissue infiltration and extracapsular spread of nodal disease influence disease-free survival.
Authors: Susan R Mallery; Gary D Stoner; Peter E Larsen; Henry W Fields; Kapila A Rodrigo; Steven J Schwartz; Qingguo Tian; Jin Dai; Russell J Mumper Journal: Pharm Res Date: 2007-02-15 Impact factor: 4.200
Authors: Kashappa Goud H Desai; Karl F Olsen; Susan R Mallery; Gary D Stoner; Steven P Schwendeman Journal: Pharm Res Date: 2010-02-11 Impact factor: 4.200
Authors: Piyush Gupta; Jocelyn C Migliacci; Pablo H Montero; Daniella Karassawa Zanoni; Jatin P Shah; Snehal G Patel; Ian Ganly Journal: Oral Oncol Date: 2018-02-20 Impact factor: 5.337
Authors: Rohan R Walvekar; Devendra A Chaukar; Mandar S Deshpande; Prathamesh S Pai; Pankaj Chaturvedi; Anagha C Kakade; Anil K D'Cruz Journal: Eur Arch Otorhinolaryngol Date: 2010-01-12 Impact factor: 2.503