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Literature DB >> 15823515

The multitude of targets for the immune system and drug therapy in the fungal cell wall.

Leonardo Nimrichter¹, Marcio L Rodrigues, Elaine G Rodrigues, Luiz R Travassos.

Abstract

Recent studies on fungi revealed that several cytosolic and membrane components migrate to the cell wall together with secreted proteins and biosynthetic polysaccharides to build a dynamic immunoreactive structure. New aspects of fungal cell wall assembly and biosynthesis, focusing on the potential of glycolipids, melanin, heat-shock proteins, histone and surface antigens as targets of drugs and antifungal antibodies are discussed.

Entities: Chemical

Mesh：

Substances：

Year: 2005 PMID： 15823515 DOI： 10.1016/j.micinf.2005.03.002

Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700

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Cited

34 in total

1. Vesicular polysaccharide export in Cryptococcus neoformans is a eukaryotic solution to the problem of fungal trans-cell wall transport.

Authors: Marcio L Rodrigues; Leonardo Nimrichter; Débora L Oliveira; Susana Frases; Kildare Miranda; Oscar Zaragoza; Mauricio Alvarez; Antonio Nakouzi; Marta Feldmesser; Arturo Casadevall
Journal: Eukaryot Cell Date: 2006-11-17

2. Structure, cellular distribution, antigenicity, and biological functions of Fonsecaea pedrosoi ceramide monohexosides.

Authors: Leonardo Nimrichter; Mariana D Cerqueira; Eduardo A Leitão; Kildare Miranda; Ernesto S Nakayasu; Sandro R Almeida; Igor C Almeida; Celuta S Alviano; Eliana Barreto-Bergter; Marcio L Rodrigues
Journal: Infect Immun Date: 2005-12 Impact factor: 3.441

Review 3. Antibody-mediated protection through cross-reactivity introduces a fungal heresy into immunological dogma.

Authors: Arturo Casadevall; Liise-anne Pirofski
Journal: Infect Immun Date: 2007-08-20 Impact factor: 3.441

4. Functional characterization of the Aspergillus nidulans glucosylceramide pathway reveals that LCB Δ8-desaturation and C9-methylation are relevant to filamentous growth, lipid raft localization and Psd1 defensin activity.

Authors: C M Fernandes; P A de Castro; A Singh; F L Fonseca; M D Pereira; T V M Vila; G C Atella; S Rozental; M Savoldi; M Del Poeta; G H Goldman; E Kurtenbach
Journal: Mol Microbiol Date: 2016-08-25 Impact factor: 3.501

Review 5. Atomic Force Microscopy: A Promising Tool for Deciphering the Pathogenic Mechanisms of Fungi in Cystic Fibrosis.

Authors: Stéphane Cuenot; Jean-Philippe Bouchara
Journal: Mycopathologia Date: 2017-11-11 Impact factor: 2.574

10. Binding of the wheat germ lectin to Cryptococcus neoformans suggests an association of chitinlike structures with yeast budding and capsular glucuronoxylomannan.

Authors: Marcio L Rodrigues; Mauricio Alvarez; Fernanda L Fonseca; Arturo Casadevall
Journal: Eukaryot Cell Date: 2007-11-26

The multitude of targets for the immune system and drug therapy in the fungal cell wall.

1. Vesicular polysaccharide export in Cryptococcus neoformans is a eukaryotic solution to the problem of fungal trans-cell wall transport.

2. Structure, cellular distribution, antigenicity, and biological functions of Fonsecaea pedrosoi ceramide monohexosides.

Review 3. Antibody-mediated protection through cross-reactivity introduces a fungal heresy into immunological dogma.

4. Functional characterization of the Aspergillus nidulans glucosylceramide pathway reveals that LCB Δ8-desaturation and C9-methylation are relevant to filamentous growth, lipid raft localization and Psd1 defensin activity.

Review 5. Atomic Force Microscopy: A Promising Tool for Deciphering the Pathogenic Mechanisms of Fungi in Cystic Fibrosis.

6. Vesicular Trans-Cell Wall Transport in Fungi: A Mechanism for the Delivery of Virulence-Associated Macromolecules?

7. Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection.

Review 8. The impact of proteomics on the understanding of functions and biogenesis of fungal extracellular vesicles.

9. Extracellular vesicles produced by Cryptococcus neoformans contain protein components associated with virulence.

10. Binding of the wheat germ lectin to Cryptococcus neoformans suggests an association of chitinlike structures with yeast budding and capsular glucuronoxylomannan.